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. 2016 Dec 15;8(4):5943–5953. doi: 10.18632/oncotarget.13966

Figure 3. Decreased expression of SFRP family genes in myostatin-deficient skeletal muscle.

Figure 3

Quantification of expression levels of SFRP (Secreted frizzled-related protein) genes, which are secreted inhibitors of Wnt signaling pathway, was performed by qRT-PCR. A significant decrease in the expression of Sfrp1 was observed in myostatin-deficient skeletal muscle at 5 (A) and 13 (B) weeks of age. In addition, a significant decrease in Sfrp5 expression was also detected in myostatin knockout mice at 5 weeks of age (A). The wild-type mice are the same age as the myostatin knockout mice. The results were normalized to the expression of Rpl26. Data are mean ± SD (n = 5). *P < 0.05, ***P < 0.001.