|
Case (n=450) |
Control (n=1050) |
P value† |
Case (n=297) |
Control (n=492) |
P value† |
Case (n=153) |
Control (n=558) |
P value† |
|
n |
Mean ±S.D |
n |
Mean ±S.D |
|
n |
Mean ±S.D |
n |
Mean ±S.D |
|
n |
Mean ±S.D |
n |
Mean ±S.D |
|
| Age (years) |
450 |
55.40±10.74 |
1050 |
52.04±8.52 |
<.0001 |
297 |
56.58±10.08 |
492 |
54.1±8.73 |
0.001 |
153 |
53.12±11.61 |
558 |
50.23±7.91 |
<0.0001 |
| ALDH2 genotype (rs671) |
|
|
|
|
0.19 |
|
|
|
|
0.54 |
|
|
|
|
0.47 |
| A/A |
|
5(1.11) |
|
22(2.10) |
|
|
4(1.35) |
|
10(2.03) |
|
|
1(0.65) |
|
12(2.15) |
|
| A/G |
|
141(31.33) |
|
292(27.81) |
|
|
103(34.68) |
|
155(31.50) |
|
|
38(24.84) |
|
137(24.55) |
|
| G/G |
|
304(67.56) |
|
736(70.10) |
|
|
190(63.97) |
|
327(66.46) |
|
|
114(74.51) |
|
409(73.30) |
|
| Alcohol intake (g/day), only among drinkers |
289 |
26.70±32.07 |
687 |
14.61±19.73 |
<.0001 |
224 |
32.34±33.96 |
405 |
20.81±22.64 |
<0.0001 |
65 |
7.26±10.72 |
282 |
5.70±8.86 |
0.28 |
| Alcohol drinking status by amount (%) |
|
|
|
<.0001 |
|
|
|
|
<0.0001 |
|
|
|
|
0.36 |
| Never/Rare drinkers (<3 g/day) |
|
183(44.85) |
|
578(55.05) |
|
|
73(27.34) |
|
148(30.08) |
|
|
110(78.01) |
|
430(77.06) |
|
| Light drinkers (3-20 g/day) |
|
90(22.06) |
|
298(28.38) |
|
|
66(24.72) |
|
186(37.80) |
|
|
24(17.02) |
|
112(20.07) |
|
| Heavy drinkers (≥20 g/day) |
|
135(33.09) |
|
174(16.57) |
|
|
128(47.94) |
|
158(32.11) |
|
|
7(4.96) |
|
16(2.87) |
|
| Smoking status (%) |
|
|
|
<.0001 |
|
|
|
|
0.002 |
|
|
|
|
0.57 |
| Non-smoker |
|
170(39.26) |
|
614(58.48) |
|
|
39(13.54) |
|
96(19.51) |
|
|
131(90.34) |
|
518(92.83) |
|
| Ex-smoker |
|
132(30.48) |
|
262(24.95) |
|
|
125(43.40) |
|
244(49.59) |
|
|
7(4.83) |
|
18(3.23) |
|
| Current smoker |
|
131(30.25) |
|
174(16.57) |
|
|
124(43.06) |
|
152(30.89) |
|
|
7(4.83) |
|
22(3.94) |
|
| Education level (%) |
|
|
|
|
<.0001 |
|
|
|
|
<0.0001 |
|
|
|
|
<0.0001 |
| <12 years |
|
153(35.42) |
|
141(14.21) |
|
|
99(34.49) |
|
57(12.45) |
|
|
54(37.24) |
|
84(15.73) |
|
| ≥12 years |
|
279(64.58) |
|
851(85.79) |
|
|
188(65.51) |
|
401(87.55) |
|
|
91(62.76) |
|
450(84.27) |
|
| Household income -10,000 KRW/month (%) |
|
|
|
<0.0001 |
|
|
|
|
<0.0001 |
|
|
|
|
0.001 |
| Below 200 |
|
151(39.22) |
|
175(18.8) |
|
|
103(40.08) |
|
70(15.98) |
|
|
48(37.50) |
|
155(21.30) |
|
| 200-400 |
|
138(35.84) |
|
424(45.54) |
|
|
99(38.52) |
|
213(48.63) |
|
|
39(30.47) |
|
211(42.80) |
|
| Above 400 |
|
96(24.94) |
|
332(35.66) |
|
|
55(21.40) |
|
155(35.39) |
|
|
41(32.03) |
|
177(35.90) |
|
| Fruit and vegetable intake (%)a,b |
|
|
|
<.0001 |
|
|
|
|
0.41 |
|
|
|
|
0.0012 |
| Lowest tertile (<426.55 g/day) |
|
193(46.06) |
|
344(33.43) |
|
|
140(50.72) |
|
224(46.09) |
|
|
53(37.06) |
|
120(22.10) |
|
| Middle tertile (<649.47 g/day) |
|
124(29.59) |
|
341(33.14) |
|
|
82(29.71) |
|
151(31.07) |
|
|
42(29.37) |
|
190(34.99) |
|
| Highest tertile (≥649.47 g/day) |
|
102(24.34) |
|
344(33.43) |
|
|
54(19.57) |
|
111(22.84) |
|
|
48(33.57) |
|
233(42.91) |
|
| H. pylori infection status (%) |
|
|
|
<.0001 |
|
|
|
|
<0.0001 |
|
|
|
|
<0.0001 |
| Positive |
|
412(91.56) |
|
639(60.86) |
|
|
272(91.58) |
|
324(65.85) |
|
|
140(91.50) |
|
315(56.45) |
|
| Negative |
|
38(8.44) |
|
411(39.14) |
|
|
25(8.42) |
|
168(34.15) |
|
|
13(8.50) |
|
243(43.55) |
|
| Family history of gastric cancer in 1st degree relatives (%) |
|
|
|
0.0002 |
|
|
|
|
0.004 |
|
|
|
|
0.11 |
| Yes |
|
93(20.67) |
|
138(13.14) |
|
|
67(22.56) |
|
71(14.43) |
|
|
26(16.99) |
|
67(12.01) |
|
| No |
|
357(79.22) |
|
912(86.86) |
|
|
230(77.44) |
|
421(85.57) |
|
|
127(83.01) |
|
491(87.99) |
|
