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. 2016 Nov 26;8(1):1416–1428. doi: 10.18632/oncotarget.13635

Figure 4. Human gDNA sequences are confined inside EVs isolated from xenografted mice.

Figure 4

AKT3, MDM4, PIK3CA, and EGFR sequences were detected in EVs isolated from the peripheral blood of 10 xenografted mice. The multiple sequence alignment shows complete homology among gDNA sequences from GBM27 hCSCs, EVs isolated from hCSCs-enriched culture supernatants, and EVs found in mouse peripheral blood. These results confirm the human origin of the sequences. Keyword: GBM1= GBM27.