Table 5. Univariate and multivariate analyses for early and late recurrence.

Factors	Testing Set				Validation Set
	Univariate		Multivariate		Univariate		Multivariate
	HR(95%CI)	P	HR(95%CI)	P	HR(95%CI)	P	HR(95%CI)	P
Early recurrence	n = 68				N = 115
AFP	0.832 (0.487-1.419)	0.038		0.586		NA		NA
Vascular invasion	0.794 (0.472-1.337)	<0.001	0.233 (0.074-0.733)	0.013	0.479 (0.297-0.772)	0.003	0.479 (0.297-0.772)	0.002
Tumor number	1.645 (0.936-2.889)	0.008		0.065	1.815 (1.094-3.011)	0.018	1.815 (1.094-3.011)	0.021
TNM stage (I-II v IIIA)		NA		NA	1.735 (1.047-2.876)	0.030	1,735 (1.047-2.876)	0.033
Later recurrence	n = 24				n = 42
ALB (≤41 v >41)	0.958 (0.346-2.658)	0.028		0.935		NA		NA
AST		NA		NA	0.581 (0.136-2.484)	0.016		0.595
FIB-4 (I/II)	2.816 (2.167-5.982)	0.003	3.035 (1.078-8.540)	0.035	1.969 (0.457-8.480)	0.001		0.466
Metavir score (F1-3/F4)	1.633 (0.507-5.261)	0.021		0.411	8.130 (2.183-30.276)	<0.001	8.699 (2.758-27.434)	<0.001

Univariate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model.

Abbreviations: HR: Hazard Ratio; AFP: alpha fetoprotein; ALB: albumin; AST: aspartate aminotransferase; NA: not adopted.