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. 2016 Nov 23;8(1):933–953. doi: 10.18632/oncotarget.13511

Figure 11. Global changes in osteosarcoma cell transcriptome following knockdown of PSMC2 expression.

Figure 11

a. Hierarchical cluster analysis of PSMC2-siRNA and normal control osteosarcoma cells. A total of 1555 genes were differentially expressed between PSMC2-siRNA and the normal osteosarcoma cells. Heat-map colors represented mean-centered fold change expression in log-space. b. Gene ontology analyses of PSMC2-regulated gene expression events. Fisher exact P-values were plotted for each category. c. Knowledge-based interaction network of PSMC2 and PSMC2 targets after comparing PSMC2-siRNA cells and control cells. The network was built based on the PSMC2 interactome of microarray data from osteosarcoma cells with a 1.5-fold change cut-off. The intensity of the node color indicates the degree of up- (red) or down- (green) regulation (light color stood for more significant P-values).