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. 2016 Dec 24;8(5):8264–8282. doi: 10.18632/oncotarget.14160

Figure 1. Identification of the interferon (IFN)-α dosage required to establish a model of IFN-α-induced depression in mice.

Figure 1

Experimental design. A. The effects of four different doses of IFN-α on depressive-like behaviors in mice. B–G. After the 28day injections of IFN-α, mice were subjected to the open field test (B–D), the sucrose preference test (E), the tail suspension test (F), and the forced swimming test (G). The total distance covered, central time, and numbers of vertical movements were measured in the open field test to identify the locomotive activities of IFN-α-treated mice. The sucrose preference (%) was detected to reflect anhedonia, the core symptom in depression. The immobility times in the tail suspension test and forced swimming test were examined to evaluate despair behavior. The results of these tests were quantified and compared among the groups. n=10 mice per group. *p< 0.05, **p< 0.01, ***p< 0.001. Error bars: means ± SEM.