Table 3. . Significant associations detected in paired-trait analysis for SLC15A2 rs1143672.
| Trait 1 (n) | Trait 2 (n) | Joint p-value | rφ |
|---|---|---|---|
| Abnormal heart sounds (290) |
ESRD (558) |
5.11 × 10-7 |
0.12 |
| Renal osteodystrophy (205) |
Pain in joint (1918) |
3.36 × 10-7 |
0.10 |
| Renal osteodystrophy (205) |
Back pain (1330) |
4.66 × 10-7 |
0.06 |
| Skin neoplasm of uncertain behavior (393) | ESRD (558) | 1.77 × 10-7 | 0.06 |
We performed joint tests of association with pairs of phecodes and the four variants in SLC15A2. Analyses were limited to pairs of codes with at least 50 individuals with both codes present; 50 individuals where both codes were absent and the correlation, rφ, was less than 0.95. Regression models in MultiPhen were adjusted for the ages of the samples at the two traits and sex. Bonferroni-corrected significance for the MultiPhen analysis in European–Americans was declared at p < 1.88 × 10- 6 (26,599 paired traits). Median correlation (rφ) of the paired traits is given for each joint test shown. p-values for tests of correlation are <0.001.
ESRD: End-stage renal disease.