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. 2016 Dec 20;8(6):9267–9279. doi: 10.18632/oncotarget.14035

Figure 9. Sirt1 inhibited ER stress-induced brown adipocyte apoptosis through the Smad3/ATF4 signal.

Figure 9

Sirt1 inhibited ER stress-induced brown adipocyte apoptosis and directly binding with ATF4. Smad3 was a novel transcriptional activator of ATF4 in alleviating ER stress and apoptosis of brown adipocytes.