Table 2. The result of subgroup analyses and sensitivity analysis.
| Variables | SEN (95% CI) | I2 | SPE (95% CI) | I2 | PLR (95% CI) | NLR (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|---|---|
| Subgroup analysis | ||||||||
| Asia | 0.82 (0.72-0.80) | 66.1 | 0.93 (0.89-0.96) | 63.7 | 10.22 (5.54-18.85) | 0.20 (0.12-0.34) | 56.40 (21.54- 147.68) | 0.92 |
| European | 0.70 (0.63-0.76) | 93.5 | 0.90 (0.86-0.93) | 87.6 | 6.42 (2.56-16.10) | 0.27 (0.10-0.74) | 24.37 (8.48- 69.99) | 0.91 |
| Sample types | ||||||||
| Serum | 0.74 (0.68-0.80) | 85.0 | 0.88 (0.84-0.92) | 0.0 | 5.69 (3.60-9.00) | 0.30 (0.17-0.55) | 19.39 (7.11- 52.90) | 0.95 |
| Sensitivity analysis | ||||||||
| Hellstrom 2010 | 0.73 (0.68-0.78) | 87.3 | 0.92 (0.89-0.94) | 80.6 | 8.29 (4.38-15.71) | 0.25 (0.15-0.44) | 33.40 (15.56- 71.72) | 0.91 |
| Macuks 2012 | 0.76 (0.72-0.80) | 89.7 | 0.93 (0.91-0.95) | 46.1 | 9.49 (6.79-13.28) | 0.21 (0.12-0.40) | 47.17 (22.35- 95.38) | 0.95 |
| Jian HQ 2012 | 0.75 (0.70-0.79) | 88.1 | 0.91 (0.88-0.93) | 71.2 | 7.22 (4.45-11.71) | 0.25 (0.14-0.43) | 46.17 (22.35- 53.62) | 0.92 |
| Yuan ZF 2012 | 0.76 (0.71-0.80) | 89.6 | 0.92 (0.89-0.94) | 80.6 | 8.52 (4.38-16.60) | 0.22 (0.12-0.42) | 38.66 (16,59- 90.06) | 0.93 |
| Zhang YJ 2013 | 0.73 (0.68-0.78) | 88.0 | 0.92 (0.89-0.94) | 79.8 | 8.99 (4.52-17.88) | 0.24 (0.13-0.43) | 38.29 (16.33- 89.78) | 0.92 |
| Wang Y 2014 | 0.77 (0.73-0.81) | 89.4 | 0.91 (0.89-0.94) | 80.4 | 8.21 (4.39-15.37) | 0.20 (0.10-0.41) | 40.24 (17.56-92.23) | 0.93 |
| Liao 2015 | 0.83 (0.79-0.87) | 55.3 | 0.90 (0.87-0.93) | 77.6 | 8.42 (4.29-16.53) | 0.20 (0.13-0.29) | 45.30 (19.89- 103.20) | 0.91 |
| Total | 0.76 (0.72-0.80) | 87.7 | 0.92 (0.89-0.94) | 76.8 | 8.39 (4.81-14.63) | 0.23 (0.13-0.39) | 37.90 (18.69-76.83) | 0.93 |
Abbreviations: SEN, sensitivity; SPE, specificity; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; CI, confidence interval.