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. 2016 Dec 26;8(6):9783–9793. doi: 10.18632/oncotarget.14189

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Copyright: © 2017 Dai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. The results from Oncomine database showed the down-regulation of FOXN3 in colon adenocarcinoma. Boxplot of FOXN3 mRNA Log2 expression levels was evaluated in Oncomine database. This study contained 19 normal colon tissues, 3 normal rectum tissues and 101 colon adenocarcinoma tissues. B. The expression of FOXN3 mRNA was down-regulated in colon cancer tissues compared with the paired normal tissues. The FOXN3 mRNA level was examined in 30 colon cancer tissues and the paired normal tissues using Real-time PCR. The expression of FOXN3 mRNA level was normalized to 18S. C. The expression of FOXN3 protein in colon cancer tissues and paired non-cancerous tissues was examined using immunohistochemistry. D. The expression of FOXN3 protein in four colon cancer tissues and paired non-cancerous tissues was examined using western blot analysis. E. The expression of FOXN3 in normal colon cells and colon cancer cells. F. Tumors formed in colon cancer mouse model Villin-Cre; P53^f/f; Ras^G12D. G. The expression of FOXN3 protein was down-regulated in the colon tissues of the mouse Villin-Cre; P53^f/f; Ras^G12D.