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. 2016 Dec 26;8(6):9783–9793. doi: 10.18632/oncotarget.14189

Figure 5. FOXN3 bind with beta-catenin and blocked the interaction between beta-catenin and TCF in colon cancer cells.

Figure 5

A. The interaction between GST-FOXN3 and beta-catenin was demonstrated in the GST pull-down assay. B. Exogenously expressed beta-catenin (Flag-beta-catenin) and FOXN3 (myc-FOXN3) formed a complex in SW620 cells in the immunoprecipitation assay. C. Endogenously expressed beta-catenin and FOXN3 formed a complex in SW620 and SW480 cells. D. The sequential immunoprecipitation assay demonstrated that FOXN3 formed a complex with beta-catenin and TCF4 in293T cells. E. The immunoprecipitation assay demonstrated that FOXN3 inhibited the interaction between beta-catenin and TCF4.