Table 4. The diagnostic accuracy of LivFib index for predicting significant fibrosis, advanced fibrosis and cirrhosis in retrospective cohort, prospective cohort and total cohort.
| Cut-off values | Positive (n) |
Negative (n) |
Sensitivity | Specificity | PPV# | NPV# | DCR# | |
|---|---|---|---|---|---|---|---|---|
| Significant Fibrosis (Ishak: 0-2 vs. 3-6) | ||||||||
| Retrospective Cohort | >3.0 | 1902 | 71 | 91.2% | 21.4% | 96.4% | 9.6% | 88.3% |
| >4.0 | 1227 | 27 | 58.9% | 70.0% | 97.8% | 6.9% | 59.3% | |
| >5.0 | 538 | 5 | 25.8% | 94.3% | 99.0% | 5.2% | 28.7% | |
| Prospective Cohort | >3.0 | 1447 | 68 | 90.4% | 16.7% | 95.5% | 8.1% | 86.8% |
| >4.0 | 920 | 27 | 57.5% | 66.7% | 97.1% | 7.4% | 57.9% | |
| >5.0 | 405 | 6 | 25.3% | 92.6% | 98.5% | 5.9% | 28.6% | |
| Total Cohort | >3.0 | 446 | 8 | 93.0% | 43.8% | 98.3% | 15.6% | 91.6% |
| >4.0 | 296 | 3 | 61.6% | 81.3% | 99.1% | 5.9% | 62.1% | |
| >5.0 | 125 | 4 | 26.3% | 77.9% | 96.9% | 3.9% | 28.1% | |
| Advanced Fibrosis (Ishak: 0-3 vs. 4-6) | ||||||||
| Retrospective Cohort | >3.0 | 1717 | 258 | 93.6% | 24.3% | 86.9% | 41.3% | 82.7% |
| >4.0 | 1154 | 101 | 62.9% | 70.3% | 91.9% | 26.1% | 64.0% | |
| >5.0 | 519 | 25 | 28.3% | 92.8% | 95.5% | 19.4% | 38.4% | |
| Prospective Cohort | >3.0 | 1242 | 322 | 94.3% | 11.6% | 79.4% | 35.9% | 76.4% |
| >4.0 | 864 | 83 | 61.7% | 70.6% | 91.3% | 27.0% | 63.2% | |
| >5.0 | 390 | 21 | 27.8% | 92.5% | 94.9% | 20.5% | 38.7% | |
| Total Cohort | >3.0 | 404 | 51 | 94.6% | 23.7% | 88.8% | 40.9% | 85.0% |
| >4.0 | 278 | 20 | 65.1% | 69.7% | 93.2% | 23.9% | 65.7% | |
| >5.0 | 124 | 4 | 29.1% | 93.4% | 96.6% | 17.1% | 37.9% | |
| Cirrhosis (Ishak: 0-4 vs. 5-6) | ||||||||
| Retrospective Cohort | >3.0 | 1462 | 513 | 95.6% | 20.7% | 74.0% | 66.5% | 73.3% |
| >4.0 | 1039 | 215 | 67.9% | 66.7% | 82.8% | 46.8% | 67.6% | |
| >5.0 | 485 | 58 | 31.7% | 91.0% | 89.3% | 36.0% | 49.3% | |
| Prospective Cohort | >3.0 | 1099 | 416 | 95.3% | 21.4% | 72.6% | 67.6% | 72.1% |
| >4.0 | 769 | 178 | 66.7% | 66.4% | 81.2% | 47.7% | 66.6% | |
| >5.0 | 363 | 48 | 31.5% | 90.9% | 88.3% | 37.8% | 50.1% | |
| Total Cohort | >3.0 | 350 | 105 | 96.1% | 19.0% | 76.9% | 63.6% | 75.9% |
| >4.0 | 256 | 42 | 70.2% | 67.3% | 85.8% | 44.6% | 69.5% | |
| >5.0 | 117 | 11 | 32.2% | 91.2% | 91.1% | 32.4% | 47.7% | |
# PPV, Positive Predictive Value; NPV, Negative Predictive Value; DCR, Diagnostic Coincidence Rate.