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. 2016 Dec 10;8(3):4373–4386. doi: 10.18632/oncotarget.13875

Figure 1. Spontaneous tumorlet development after ablation of Rb family members in adult TKO lungs.

Figure 1

(A) Tumor latency of TKO mice. (B) Example of an external view of a tumorlet (arrow) in the lung 17 months after cre delivery. (C) Histology of a tumorlet composed of a uniform population of cells. (D–I). Immunohistochemical staining for the quoted proteins. Representative images are shown. Positive immunostaining for N-cam1 (D), ChrA (E) ,Syn(F) and TTF-1 (G), and negative for proSPC (H) and CC-10 (I). HE hematoxylin and eosin stain. Bars = 50 μm