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. 2016 Dec 22;8(3):5160–5178. doi: 10.18632/oncotarget.14107

Figure 4. DNA replication is triggered by the same circuits in KIRC and BRCA, but using a different pattern of gene activation.

Figure 4

The Hipathia program (http://hipathia.babelomics.org) detected a total of four effector circuits in two pathways, Cell Cycle and P53 signaling, that are used by both cancers to trigger DNA replication. Arrows in red represent activated circuits. Genes in red represent genes upregulated in the cancer with respect to the corresponding normal tissue; genes in blue represent downregulated genes and genes with no color were not differentially expressed. Squares at the end of the circuit represent the cell functions triggered by the circuits. A. Cell Cycle signaling pathway in KIRC with three effector circuits activated (highlighted), one of them ending in the node containing proteins CDC6, ORC3, ORC5, ORC4, ORC2, ORC1 and ORC6, the second one ending in node with proteins CDC45, MCM7, MCM6, MCM5, MCM4, MCM3 and MCM2 and the last one ending in node with proteins ORC3, ORC5, ORC4, ORC2, ORC1, ORC6, MCM7, MCM6, MCM5, MCM4, MCM3 and MCM2. B. P53 signaling pathway in BRCA with the effector circuit ending in protein RRM2B highlighted. C. Cell Cycle pathway in BRCA with the same effector circuits activated that in KIRC, but using a different set of gene activations. D. P53 signaling pathway in BRCA with the same effector circuit activated that in KIRC, but using a different set of gene activations.