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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Haemophilia. 2017 Jan 25;23(2):e93–e98. doi: 10.1111/hae.13157

Fig. 3.

Fig. 3

Peri-operative r-pFVIII replacement schedule and resulting peak and trough FVIII activity levels. Peri-operative dosing of r-pFVIII (closed triangles, ▼) was initiated at a dose of 170 IU/kg at the time of incision for aortic repair, hour 0. Subsequent doses of 100 IU/kg were administered at increasing intervals as indicated. Peak FVIII activity levels (open diamonds, ◊) and trough FVIII activity levels (closed squares, ▪) sampled around early post-operative doses and at later points when r-pFVIII activity was less sustained.