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. 2016 Dec 25;8(8):12902–12916. doi: 10.18632/oncotarget.14186

Figure 8. Proposed redox-mediated down-regulation of Bcl-2 and apoptosis induce by heat stress in HUVEC cells.

Figure 8

Our study provides evidence that superoxide may be a key mediator of heat stress-induced apoptosis through a mechanism related to Bcl-2 down-regulation and activation of the mitochondrial apoptotic pathway in HUVEC cells. Superoxide appears to act as an upstream signaling molecule involved in Bcl-2 down-regulation via ubiquitin–proteasomal degradation that is triggered by inactivation of ERK1/2.