Figure 5. Schematic model illustrating the cellular signaling involved in the effects of TRPM7 potentiation on U87 migration and invasion.

The TRPM7 channel can respond to extracellular or cytosolic stimuli through regulation of Ca²⁺ and Mg²⁺ influx. In addition, TRPM7 contains a self-phosphorylating α-type Ser/Thr protein kinase domain that also modulates the phosphorylation of other cytosolic substrates such as PLC, which in turn, can regulate MAPK/ERK signaling. Consequently, functional gene transcription and translation are affected. Naltriben potentiates TRPM7, which upregulates MAPK/ERK signaling, and ultimately enhances U87 migration and invasion.