Figure 2. Cohesion defects in various DDX11 and ESCO2 mutants.

A.-D. Chromosomes from metaphase spreads were classified in three groups (A), and more than 100 metaphase cells were analyzed for each genotype (B-D). Independently prepared slides, from a different biological experiment, were used to confirm the trend. (D) DDX11 cells with hSA2-12A were incubated with or without Dox, to induce expression of hSA2-12A, for 24 h and metaphase spread samples were examined as in (B-C).