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. 2016 Nov 8;7(51):84705–84717. doi: 10.18632/oncotarget.13224

Figure 5. Estrogen receptor positive patients with high KCNJ3 mRNA levels in their tumor have a worse overall and disease free survival probability.

Figure 5

(A) Kaplan-Meier plot showing overall survival of ER positive patients of the TCGA data set with low and high KCNJ3 mRNA expression levels as determined by RNAseq (n = 647). (B) Representative RNA in situ hybridization of a patient with low KCNJ3 levels in the tumor (0.16 spots/cell) and long survival times. (C) Representative RNA in situ hybridization of a patient with high KCNJ3 levels in the tumor (6.69 spots/cell) and short survival times. (D) Kaplan-Meier plot showing overall survival of a subset of patients of the GEO data set GSE17705 with low and high KCNJ3 mRNA expression levels as determined by RNA in situ hybridization (n = 54). (E) Same as (D), but showing disease free survival. Hazard ratios and logrank p-values are given in Kaplan-Meier plots. Scale bar in (B) and (C): 20μm. DFS: disease free survival; OS: overall survival.