Table 1. Cox-proportional hazard models for estrogen receptor positive breast cancer patients.

		univariate Cox modela		multivariate Cox modelb		multivariate Cox modelc
		HR (95%-CI)	p-value	HR(95%-CI)	p-value	HR(95%-CI)	p-value
Size (T)	T1 vs. T2|T3|T4	1.0 (0.6–1.8)	0.985	4.2 (0.5–36.2)	0.184	5.9 (0.7–53.9)	0.113
Lymph node status (N)	neg. vs. pos.	1.8 (1.0–3.2)	0.042	0.7 (0.2–2.4)	0.612	0.7 (0.2–2.2)	0.513
Metastasis status (M)	neg.vs.pos.	3.5 (1.5–8.3)	0.004	3.9 (0.7–21.4)	0.112	4.3 (0.8–23.2)	0.092
Histology	ductal vs. lobular	0.6 (0.1–2.4)	0.454	0.6 (0.1–3.2)	0.538	0.5(0.1–3.3)	0.539
Her2 status	neg. vs. pos.	1.1 (0.4–2.8)	0.845	1.2 (0.1–10.3)	0.894	2.2 (0.2–22.5)	0.517
Menopause status	prem. vs. postm.	2.5 (0.9–7.0)	0.092	0.9(0.04–18.4)	0.928	0.6(0.02–20.9)	0.753
Age at diagnosis	≤50 vs. > 50 years	1.9 (1.0–3.4)	0.038	3.2 (0.9–11.1)	0.812	2.7(0.1–116.0)	0.589
PAM50 status	Luminal A vs. Luminal B	2.6 (1.3–5.3)	0.006	3.2 (0.1–32.5)	0.071	1.5(0.4–5.9)	0.589
KCNJ3 expression	low(≤ 72th %ile) vs. high (> 72th %ile)	1.8(1.0–3.0)	0.036			5.2(1.3–21.8)	0.021

^an = 646

^bwithout KCNJ3 mRNA expression, n = 228

^cwith KCNJ3 mRNA expression, n = 228

Abbreviations: neg.: negative; pos.: positive; prem.: premenopausal; postm.: postmenopausal; HR: hazard ratio; CI: confidence interval