Table 5. Effects of five SNPs on breast cancer risk as stratified by expression of ER, PR, and HER-2.
| Genotype | Co | ER (-) | ER (+) | PR (-) | PR (+) | HER-2 (-) | HER-2 (+) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ca | OR(95% CI)* | P value | Ca | OR(95% CI)* | P value | Ca | OR(95% CI)* | P value | Ca | OR(95% CI)* | P value | Ca | OR(95% CI)* | P value | Ca | OR(95% CI)* | P value | ||
| XPA rs1800975 | |||||||||||||||||||
| GG | 93 | 51 | Reference | 64 | Reference | 61 | Reference | 54 | Reference | 27 | Reference | 88 | Reference | ||||||
| GA | 231 | 86 | 0.67(0.44,1.03) | 0.067 | 149 | 0.93(0.64,1.36) | 0.718 | 109 | 0.72(0.49,1.08) | 0.113 | 126 | 0.93(0.62,1.39) | 0.720 | 46 | 0.69(0.41,1.18) | 0.177 | 189 | 0.86(0.60,1.22) | 0.399 |
| AA | 106 | 35 | 0.60(0.36,1.01) | 0.055 | 65 | 0.89(0.57,1.39) | 0.602 | 42 | 0.61(0.37,0.99) | 0.044 | 58 | 0.94(0.59,1.49) | 0.786 | 24 | 0.78(0.42,1.45) | 0.432 | 76 | 0.76(0.50,1.15) | 0.196 |
| GA/AA | 337 | 121 | 0.65(0.44,0.98) | 0.038 | 214 | 0.92(0.64,1.33) | 0.670 | 151 | 0.69(0.47,1.00) | 0.053 | 184 | 0.94(0.64,1.38) | 0.747 | 70 | 0.73(0.44,1.20) | 0.212 | 265 | 0.83(0.60,1.16) | 0.284 |
| ERCC1 rs11615 | |||||||||||||||||||
| CC | 261 | 98 | Reference | 132 | Reference | 119 | Reference | 111 | Reference | 47 | Reference | 183 | Reference | ||||||
| TC | 151 | 70 | 1.23(0.85,1.78) | 0.276 | 125 | 1.63(1.18,2.24) | 0.003 | 82 | 1.16(0.82,1.64) | 0.414 | 113 | 1.78(1.28,2.48) | 0.001 | 48 | 1.73(1.10,2.72) | 0.018 | 147 | 1.38(1.03,1.87) | 0.034 |
| TT | 18 | 4 | 0.58(0.19,1.76) | 0.333 | 21 | 2.28(1.17,4.44) | 0.015 | 11 | 1.34(0.61,2.94) | 0.463 | 14 | 1.81(0.87,3.77) | 0.114 | 2 | 0.66(0.15,2.95) | 0.585 | 23 | 1.80(0.94,3.44) | 0.075 |
| TC/TT | 169 | 74 | 1.16(0.81,1.66) | 0.432 | 146 | 1.68(1.24,2.29) | 0.001 | 93 | 1.17(0.84,1.64) | 0.352 | 127 | 1.76(1.28,2.43) | 0.001 | 50 | 1.61(1.03,2.51) | 0.037 | 170 | 1.41(1.06,1.88) | 0.018 |
| XPC rs2228000 | |||||||||||||||||||
| CC | 228 | 84 | Reference | 117 | Reference | 96 | Reference | 105 | Reference | 41 | Reference | 160 | Reference | ||||||
| CT | 174 | 67 | 1.06(0.72,1.54) | 0.773 | 131 | 1.48(1.08,2.04) | 0.016 | 88 | 1.23(0.86,1.75) | 0.257 | 110 | 1.38(0.99,1.92) | 0.059 | 41 | 1.32(0.82,2.12) | 0.257 | 157 | 1.30(0.97,1.75) | 0.082 |
| TT | 28 | 21 | 2.27(1.20,4.26) | 0.011 | 30 | 2.15(1.22,3.78) | 0.008 | 28 | 2.62(1.45,4.73) | 0.001 | 23 | 1.83(1.00,3.34) | 0.049 | 15 | 3.09(1.50,6.36) | 0.002 | 36 | 1.93(1.12,3.31) | 0.017 |
| CT/TT | 202 | 88 | 1.21(0.85,1.72) | 0.299 | 161 | 1.58(1.16,2.14) | 0.004 | 116 | 1.41(1.01,1.96) | 0.045 | 133 | 1.44(1.05,1.98) | 0.026 | 56 | 1.55(0.99,2.42) | 0.055 | 193 | 1.39(1.04,1.84) | 0.025 |
| XPC rs2228001 | |||||||||||||||||||
| AA | 161 | 72 | Reference | 121 | Reference | 94 | Reference | 99 | Reference | 43 | Reference | 150 | Reference | ||||||
| AC | 213 | 79 | 0.81(0.55,1.19) | 0.277 | 116 | 0.72(0.52,1.00) | 0.051 | 90 | 0.71(0.49,1.01) | 0.055 | 105 | 0.80(0.57,1.13) | 0.202 | 42 | 0.74(0.46,1.20) | 0.220 | 153 | 0.76(0.56,1.04) | 0.085 |
| CC | 56 | 21 | 0.80(0.45,1.42) | 0.444 | 41 | 0.97(0.60,1.55) | 0.894 | 28 | 0.81(0.48,1.37) | 0.436 | 34 | 0.99(0.60,1.62) | 0.958 | 12 | 0.77(0.38,1.58) | 0.482 | 50 | 0.94(0.60,1.47) | 0.790 |
| AC/CC | 269 | 100 | 0.81(0.56,1.16) | 0.251 | 157 | 0.77(0.57,1.05) | 0.098 | 118 | 0.73(0.52,1.02) | 0.066 | 139 | 0.84(0.61,1.16) | 0.284 | 54 | 0.75(0.48,1.18) | 0.213 | 203 | 0.80(0.60,1.07) | 0.133 |
| ERCC2/XPD rs50872 | |||||||||||||||||||
| CC | 290 | 89 | Reference | 180 | Reference | 113 | Reference | 156 | Reference | 58 | Reference | 211 | Reference | ||||||
| CT | 126 | 73 | 1.86(1.28,2.71) | 0.001 | 87 | 1.10(0.79,1.53) | 0.588 | 85 | 1.71(1.20,2.43) | 0.003 | 75 | 1.09(0.77,1.55) | 0.621 | 36 | 1.43(0.89,2.28) | 0.136 | 124 | 1.33(0.98,1.81) | 0.069 |
| TT | 14 | 10 | 2.44(1.04,5.73) | 0.040 | 11 | 1.27(0.56,2.86) | 0.565 | 14 | 2.61(1.20,5.68) | 0.016 | 7 | 0.93(0.37,2.36) | 0.882 | 3 | 1.08(0.30,3.90) | 0.905 | 18 | 1.80(0.88,3.72) | 0.110 |
| CT/TT | 140 | 83 | 1.92(1.34,2.76) | 0.000 | 98 | 1.11(0.81,1.53) | 0.518 | 99 | 1.80(1.28,2.52) | 0.001 | 82 | 1.08(0.77,1.51) | 0.658 | 39 | 1.39(0.88,2.19) | 0.157 | 142 | 1.38(1.03,1.85) | 0.033 |
*
Adjusted by age and menopausal status; Ca, case; Co, control.