Figure 1. The levels of NF-κB p65 and HO-1 were increased during aging.

The stress-sensitive inflammatory factor NF-κB p65 increased significantly in the mRNA A. and protein levels of SAMP8 mice B., C. The downstream detoxifying and antioxidant enzyme HO-1 was increased gradually both at gene expression D. and protein level E., F. in aging process. 4M, 8M, 12M represent 4 month, 8 month and 12 month, respectively. Data are mean ±SD, *P < 0.05, ** P < 0.01.