Table 1. Characteristics of meningioma cases and controls.
| Variable | Number of cases(%)(n=2,027) | Number of controls(%)(n=20,269) | OR (95% CI)* | p-value |
|---|---|---|---|---|
| Age (years)* | ||||
| 0–9 | 1 (0.1) | 10 (0.1) | - | - |
| 10–19 | 17 (0.8) | 173 (0.9) | - | - |
| 20–29 | 24 (1.2) | 261 (1.3) | - | - |
| 30–39 | 117 (5.8) | 1,161 (5.7) | - | - |
| 40–49 | 301 (14.9) | 3,018 (14.9) | - | - |
| 50–59 | 396 (19.5) | 3,963 (19.6) | - | - |
| 60–69 | 455 (22.5) | 4,526 (22.3) | - | - |
| 70–79 | 461 (22.7) | 4,638 (22.9) | - | - |
| 80–90 | 255 (12.6) | 2,519 (12.4) | ||
| Sex* | ||||
| Women | 1,534 (75.7) | 15,340 (75.7) | - | - |
| Men | 493 (24.3) | 4,929 (24.3) | - | - |
| Smoking status | ||||
| Never smoker | 1,103 (54.4) | 10,247 (50.6) | 1.00 (referent) | - |
| Current smoker | 308 (15.2) | 3,249 (16.0) | 0.87 (0.76–1.00) | 0.050 |
| Past smoker | 450 (22.2) | 4,782 (23.6) | 0.87 (0.77–0.98) | 0.024 |
| Unknown | 166 (8.2) | 1,991 (9.8) | 0.74 (0.61–0.89) | 0.002 |
| Comorbidities | ||||
| Stroke/TIA | 89 (4.4) | 958 (4.7) | 0.92 (0.73–1.16) | 0.481 |
| MI | 45 (2.2) | 656 (3.2) | 0.67 (0.49–0.91) | 0.011 |
| CHF | 43 (2.12) | 449 (2.5) | 0.85 (0.61–1.18) | 0.326 |
| Diabetes | 145 (7.2) | 1,465 (7.2) | 0.99 (0.82–1.19) | 0.899 |
| Comedications | ||||
| Estrogens+ | ||||
| No prior use | 1,182 (77.1) | 12,196 (79.5) | 1.00 (reference) | - |
| 1–8 Rx | 162 (10.6) | 1,323 (8.6) | 1.31 (1.09–1.57) | 0.004 |
| ≥ 9 Rx | 190 (12.4) | 1,821 (11.9) | 1.12 (0.94–1.34) | 0.206 |
*
Matching variables: age, sex, general practice, and number of years of active history in the database.
+
Women only.
TIA: transient ischemic attack, MI: myocardial infarction; CHF: congestive heart failure; OR: odds ratio CI: confidence intervals.