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. 2016 Nov 29;8(2):3144–3155. doi: 10.18632/oncotarget.13673

Figure 3. RNF2 promotes HCC cell proliferation by accelerating cell-cycle progression.

Figure 3

A and B. Cell cycle analysis of HCC cells treated with sh-RNF2 or HCC cells treated with pCDNA-RNF2-wt for 48 hours. The bar chart represents the percentage of cells in the G1-G0, S, or G2-M phase, as indicated. C and D. RNF2-knockdown HCC cells conferred a large subgroup of apoptotic cells as compared with control cells, whereas overexpression of RNF2 didn't affect apoptosis as compared with the control. These data are expressed as the mean ± SD. The results are representative of three independent experiments. *P < 0.05, **P < 0.01. Statistical significance was concluded at *P < 0.05, **P < 0.01, ***P < 0.001; # represents no statistical significance.