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. 1969 Mar;48(3):432–442. doi: 10.1172/JCI106000

Effects of potassium deficiency on renal function in the dog

Peter H Abbrecht 1
PMCID: PMC535707  PMID: 5773081

Abstract

Serial determinations of the renal clearance for inulin and para-aminohippuric acid (PAH), maximum renal tubular reabsorptive rate for glucose, maximum urinary concentrating ability, total exchangeable potassium, extracellular volume, and plasma sodium and potassium concentrations were done in seven dogs before and after dietary potassium depletion. The same measurements were also made in two of the dogs during potassium repletion.

Inulin and PAH clearances and transport maxima for glucose decreased progressively during depletion. These changes correlated well with both the duration of depletion and the extent of depletion as measured by total exchangeable potassium. Decreases in inulin and PAH clearance closely paralleled each other, suggesting that there might be a renal hemodynamic basis for both effects. The decreases in transport maxima for glucose were greater than those for inulin or PAH clearance, indicating the presence of a defect in the cellular transport mechanism for glucose. In the dogs that were repleted, renal function gradually returned to the predepletion state.

No significant changes were found in extracellular volume or plasma sodium concentration during depletion. Renal concentrating ability decreased only moderately during depletion, with the decrease correlating better with plasma potassium concentration than with total exchangeable potassium. This finding contrasts with the marked decrease in concentrating ability and the severe polydipsia and polyuria found in animals depleted of potassium with the aid of corticosteroids. The results of the present study emphasize the importance of considering species differences and the method of producing depletion in interpreting studies of the effects of hypokalemia on renal function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALDWIN D. S., SCHREINER G. E., BREED E. S., WESSON L. G., Jr, MAXWELL M. H. Depression of apparent p-aminohippurate extraction ratio by glucose. J Clin Invest. 1950 May;29(5):614–618. doi: 10.1172/JCI102298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BESKIND H., MUDGE G. H. Effect of potassium deficiency on renal tubular reabsorption and assimilation of glucose. Bull Johns Hopkins Hosp. 1959 May;104(5):252–259. [PubMed] [Google Scholar]
  3. BLAINEY J. D., COOKE W. T., QUINTON A., SCOTT K. W. The measurement of total exchangeable potassium in man, with particular reference to patients with steatorrhoea. Clin Sci. 1954 Feb;13(1):165–176. [PubMed] [Google Scholar]
  4. FROHLICH E. D., SCOTT J. B., HADDY F. J. Effect of cations on resistance and responsiveness of renal and forelimb vascular beds. Am J Physiol. 1962 Sep;203:583–587. doi: 10.1152/ajplegacy.1962.203.3.583. [DOI] [PubMed] [Google Scholar]
  5. GIEBISCH G., LOZANO R. The effects of adrenal steroids and potassium depletion on the elaboration of an osmotically concentrated urine. J Clin Invest. 1959 May;38(5):843–853. doi: 10.1172/JCI103866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HADDY F. J., SCOTT J. B., FLORIO M. A., DAUGHERTY R. M., Jr, HUIZENGA J. N. Local vascular effects of hypokalemia, alkalosis, hypercalcemia, and hypomagnesemia. Am J Physiol. 1963 Feb;204:202–212. doi: 10.1152/ajplegacy.1963.204.2.202. [DOI] [PubMed] [Google Scholar]
  7. HANDLEY C. A., SIGAFOOS R. B., LA FORGE M. Proportional changes in renal tubular reabsorption of dextrose and excretion of p-amino-hippurate with changes in glomerular filtration. Am J Physiol. 1949 Oct;159(1):175–180. doi: 10.1152/ajplegacy.1949.159.1.175. [DOI] [PubMed] [Google Scholar]
  8. HOLLIDAY M. A., SEGAR W. E., BRIGHT N. H., EGAN T. The effect of potassium deficiency on the kidney. Pediatrics. 1960 Dec;26:950–959. [PubMed] [Google Scholar]
  9. OLIVER J., MACDOWELL M., WELT L. G., HOLLIDAY M. A., HOLLANDER W., Jr, WINTERS R. W., WILLIAMS T. F., SEGAR W. E. The renal lesions of electrolyte imbalance. I. The structural alterations in potassium-depleted rats. J Exp Med. 1957 Oct 1;106(4):563–574. doi: 10.1084/jem.106.4.563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. RELMAN A. S., SCHWARTZ W. B. The nephropathy of potassium depletion; a clinical and pathological entity. N Engl J Med. 1956 Aug 2;255(5):195–203. doi: 10.1056/NEJM195608022550501. [DOI] [PubMed] [Google Scholar]
  11. RUBINI M. E. Water excrtion in potassium-deficient man. J Clin Invest. 1961 Dec;40:2215–2224. doi: 10.1172/JCI104448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SCHREINER G. E. Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med. 1950 May;74(1):117–120. doi: 10.3181/00379727-74-17827. [DOI] [PubMed] [Google Scholar]
  13. SCHWARTZ W. B., RELMAN A. S. Metabolic and renal studies in chronic potassium depletion resulting from overuse of laxatives. J Clin Invest. 1953 Mar;32(3):258–271. doi: 10.1172/JCI102735. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SCOTT J., EMANUEL D., HADDY F. Effect of potassium on renal vascular resistance and urine flow rate. Am J Physiol. 1959 Aug;197:305–308. doi: 10.1152/ajplegacy.1959.197.2.305. [DOI] [PubMed] [Google Scholar]
  15. SCRIBNER B. H., BURNELL J. M. Interpretation of the serum potassium concentration. Metabolism. 1956 Jul;5(4):468–479. [PubMed] [Google Scholar]
  16. Smith H. W., Finkelstein N., Aliminosa L., Crawford B., Graber M. THE RENAL CLEARANCES OF SUBSTITUTED HIPPURIC ACID DERIVATIVES AND OTHER AROMATIC ACIDS IN DOG AND MAN. J Clin Invest. 1945 May;24(3):388–404. doi: 10.1172/JCI101618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WELT L. G., HOLLANDER W., Jr, BLYTHE W. B. The consequences of potassium depletion. J Chronic Dis. 1960 Mar;11:213–254. doi: 10.1016/0021-9681(60)90038-2. [DOI] [PubMed] [Google Scholar]
  18. Worcester J. The statistical method. N Engl J Med. 1966 Jan 6;274(1):27–36. doi: 10.1056/NEJM196601062740106. [DOI] [PubMed] [Google Scholar]
  19. van Liew J. B., Deetjen P., Boylan J. W. Glucose reabsorption in the rat kidney. Dependence on glomerular filtration. Pflugers Arch Gesamte Physiol Menschen Tiere. 1967;295(3):232–244. doi: 10.1007/BF01844103. [DOI] [PubMed] [Google Scholar]

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