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. 1969 Mar;48(3):443–453. doi: 10.1172/JCI106001

Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia

Robert S Hillman 1
PMCID: PMC535708  PMID: 5773082

Abstract

Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity. This study permitted a comparison of marrow production measurements over a wide range of marrow production levels. As long as the serum iron remained above 50 μg/100 ml, measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production. In contrast, the absolute reticulocyte count demonstrated a poor correlation with the other measurements. This was shown to be the result of a prolongation of the time required for circulating reticulocytes to lose their reticulum, which correlated with the severity of the anemia. For the clinical application of the reticulocyte count as a measurement of marrow production, an adjustment must be made for this alteration in the circulating reticulocyte maturation time.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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