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The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1969 Mar;48(3):454–460. doi: 10.1172/JCI106002

Control of marrow production by the level of iron supply

Robert S Hillman 1, Perry A Henderson 1
PMCID: PMC535709  PMID: 5773083

Abstract

The level of erythroid marrow production varies widely in different erythropoietic disorders. In part, this reflects the level of erythropoietin stimulation as determined by the severity of the anemia. However, iron supply plays an equally important role in the control of erythropoiesis. As demonstrated in normal individuals subjected to prolonged periods of phlebotomy-induced anemia, the erythroid marrow will increase production by as little as twice to as much as eight times normal, depending on the iron supply available from different iron pools. Whereas the iron delivered from normal reticuloendothelial stores or orally administered iron is sufficient for a marrow production response of only two to three times normal, the increased iron supply from nonviable red cells, hemolysis, or iron dextran infusions permits marrow production to rise acutely to levels of four to eight times normal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOTHWELL T. H., HURTADO A. V., DONOHUE D. M., FINCH C. A. Erythrokinetics. IV. The plasma iron turnover as a measure of erythropoiesis. Blood. 1957 May;12(5):409–427. [PubMed] [Google Scholar]
  2. BOTHWELL T. H., MALLETT B. The determination of iron in plasma or serum. Biochem J. 1955 Apr;59(4):599–602. doi: 10.1042/bj0590599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. COLEMAN D. H., DONOHUE D. M., FINCH C. A., MOTULSKY A. G., REIFF R. H. Erythrokinetics in pernicious anemia. Blood. 1956 Sep;11(9):807–820. [PubMed] [Google Scholar]
  4. COLEMAN D. H., STEVENS A. R., Jr, DODGE H. T., FINCH C. A. Rate of blood regeneration after blood loss. AMA Arch Intern Med. 1953 Sep;92(3):341–349. doi: 10.1001/archinte.1953.00240210045006. [DOI] [PubMed] [Google Scholar]
  5. CROSBY W. H., AKEROYD J. H. The limit of hemoglobin synthesis in hereditary hemolytic anemia; its relation to the excretion of bile pigment. Am J Med. 1952 Sep;13(3):273–283. doi: 10.1016/0002-9343(52)90282-9. [DOI] [PubMed] [Google Scholar]
  6. FINCH C. A., STURGEON P. Erythrokinetics in Cooley's anemia. Blood. 1957 Jan;12(1):64–73. [PubMed] [Google Scholar]
  7. FINCH S., HASKINS D., FINCH C. A. Iron metabolism; hematopoiesis following phlebotomy; iron as a limiting factor. J Clin Invest. 1950 Aug;29(8):1078–1086. doi: 10.1172/JCI102339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GIBLETT E. R., COLEMAN D. H., PIRZIOBIROLI G., DONOHUE D. M., MOTULSKY A. G., FINCH C. A. Erythrokinetics: quantitative measurements of red cell production and destruction in normal subjects and patients with anemia. Blood. 1956 Apr;11(4):291–309. [PubMed] [Google Scholar]
  9. HUFF R. L., ELMLINGER P. J., GARCIA J. F., ODA J. M., COCKRELL M. C., LAWRENCE J. H. Ferrokinetics in normal persons and in patients having various erythropoietic disorders. J Clin Invest. 1951 Dec;30(122):1512–1526. doi: 10.1172/JCI102562. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. HUFF R. L., HENNESSY T. G., AUSTIN R. E., GARCIA J. F., ROBERTS B. M., LAWRENCE J. H. Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disorders. J Clin Invest. 1950 Aug;29(8):1041–1052. doi: 10.1172/JCI102335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LAWRENCE J. H., ELMLINGER P. J., FULTON G. Oxygen and the control of red cell production in primary and secondary polycythemia; effects on the iron turnover patterns with Fe59 as tracer. Cardiologia. 1952;21(4):337–346. doi: 10.1159/000165213. [DOI] [PubMed] [Google Scholar]
  12. LAWRENCE J. H., HUFF R. L., SIRI W., WASSERMAN L. R., HENNESSY T. G. A physiological study in the Peruvian Andes. Acta Med Scand. 1952 Feb 23;142(2):117–131. doi: 10.1111/j.0954-6820.1952.tb13851.x. [DOI] [PubMed] [Google Scholar]
  13. MORGAN E. H., CARTER G. Plasma iron and iron-binding capacity levels in health and disease: with an improved method for the estimation of plasma iron concentration and total iron-binding capacity. Australas Ann Med. 1960 Aug;9:209–213. doi: 10.1111/imj.1960.9.3.209. [DOI] [PubMed] [Google Scholar]
  14. REYNAFARJE C., LOZANO R., VALDIVIESO J. The polycythemia of high altitudes: iron metabolism and related aspects. Blood. 1959 Apr;14(4):433–455. [PubMed] [Google Scholar]
  15. SHARP A. A. Viscous metamorphosis of blood platelets; a study of the relationship to coagulation factors and fibrin formation. Br J Haematol. 1958 Jan;4(1):28–37. doi: 10.1111/j.1365-2141.1958.tb03831.x. [DOI] [PubMed] [Google Scholar]

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