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. 1970 May;49(5):907–913. doi: 10.1172/JCI106310

Warfarin metabolism in man: identification of metabolites in urine

Richard J Lewis 1,2,3, William F Trager 1,2,3
PMCID: PMC535763  PMID: 5441544

Abstract

After administration of the coumarin anticoagulant racemic warfarin to normal humans, seven fluorescent compounds were chromatographically separated from extracts of their urine. Four of these were identified using mass spectrometry, thin-layer chromatography, and ultraviolet absorption spectroscopy. One metabolic pathway, reduction of the acetonyl side chain of warfarin, resulted in the formation of a second asymmetric carbon atom, and two diastereoisomer alcohols were identified. These warfarin alcohols are structurally similar to pharmacologically active coumarin derivatives. They have not been reported in animal studies. In addition, 6- and 7-hydroxywarfarin were identified. These are the first studies to document the metabolic fate of warfarin in the normal human.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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