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. 1970 Nov;49(11):1993–1998. doi: 10.1172/JCI106419

Mechanism of action of thyroid hormones on erythrocyte 2,3-diphosphoglyceric acid synthesis

L Michael Snyder 1,2, William J Reddy 1,2
PMCID: PMC535777  PMID: 5475983

Abstract

Normal erythrocytes, when incubated with thyroid hormone, were found to have increased levels of 2,3-diphosphoglyceric acid. In addition, a partially purified enzyme preparation, when incubated with either a 1,3-diphosphoglyceric acid generating system or 1,3-diphosphoglyceric acid directly, showed increased levels of 2,3-diphosphoglyceric acid when exposed to thyroid hormone. The hormonal effect was biphasic and was witnessed after 5 min of incubation. Substitution on the 3 and 5 positions of the basic thyronine molecule was essential for hormonal effect. It appears that thyroid hormone acts by directly stimulating the diphosphoglycerate mutase enzyme. The hormonal effect on 2,3-DPG synthesis may offer a biochemical explanation for the shift in the oxyhemoglobin dissociation curve observed in thyroid disorders.

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1993

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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