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Lysyl oxidase propeptide (LOX-PP) inhibited phosphorylation of ERK1/2 and AKT, two key mediators of FGF-2 receptor signaling. (A) LOX-PP dose dependently inhibited ERK1/2 phosphorylation; (B) LOX-PP dose dependently inhibited AKT phosphorylation; (C) LOX-PP inhibited the prolifreative response of 3T3-L1 cells induced by FGF-2 treatment. (Means ± SEM; *vs. cells without FGF-2 and LOX-PP treatments, P < 0.05; #vs. cells with 5 ng/ml FGF-2 without LOX-PP, P < 0.05).
