IL-6 signaling in eWAT and iWAT. iWAT mRNA expression of A) IL-6, B) SOCS3, along with the protein content of C) pSTAT3/STAT3. eWAT mRNA expression of D) IL-6, E) SOCS3, along with the protein content of F) pSTAT3/STAT3. Representative blots for pSTAT3 and STAT3 are shown beside each panel, and the inset figure indicates the relative change induced by LPS within SED and VWR groups. Data is presented as mean ± sem (n = 5–10/group). A two-way ANOVA main effect (indicated by a flat bar), post-hoc testing of significant interactions (indicated by lines with ticks), or results of unpaired t-test (relative change inset) have significance displayed for LPS as ***p < 0.001, and ****p < 0.0001 and for VWR as †p < 0.05, ††p < 0.01, †††p < 0.001, and ††††p < 0.0001.