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. 2017 Feb 21;8(1):e01976-16. doi: 10.1128/mBio.01976-16

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Copyright © 2017 Moradigaravand et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — (A) Dated Bayesian phylogenies for the United Kingdom and Ireland STs that contain at least 10 United Kingdom and Ireland MDR K. pneumoniae isolates. The bars on the nodes show 95% confidence intervals. The values on the nodes denote divergence times in years. The colored bars in the columns next to each clade show putative outbreaks in the same hospitals. The most recent collection years of isolates in the ST15, ST147, ST874, ST101, and ST16 clades were 2013, 2012, 2009, 2010, and 2013, respectively. (B) Substitution rates estimated for the clades in panel A. The error bars denote the 95% confidence interval. (C) The age of the MRCA of the clades in panel A. The error bars denote 95% confidence intervals. (D) Dates of the MRCA of United Kingdom and Ireland isolates and global isolates for the isolates not present in the major ST clades shown in panel A. The estimated age of divergence between United Kingdom and global isolates for linkages within a cutoff of 80 SNPs corresponds to ~20 years. This age and the upper and lower values of the error bar (95% confidence interval) were obtained by dividing the pairwise SNP distances by the mean substitution rate and also the upper and lower 95% confidence interval bounds for the substitution values in panel B.