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Effect of α-AR blockade on insulin sensitivity in cold-exposed rats during a euglycemic-hyperinsulinemic clamp. Arterial blood glucose (A), plasma insulin (B), GIR (C), and mean GIR (D) during the last 30 min required to maintain euglycemia during a euglycemic-hyperinsulinemic clamp in cold-exposed rats (4°C for 28 h) given a continuous i.v. infusion of phentolamine (8 μg/kg/min) or vehicle. Mean ± SEM. *P < 0.05 vs. vehicle.
