Table 1.
Highest and lowest frequencies (%) reported for 17 CYP allelic variants.
| CYP variant | Highest reported frequency (%) (population) | Lowest reported frequency (%) (population) |
|---|---|---|
| CYP2B6*6 | 69 (Uganda) | 9 (South Africa MA) |
| CYP2C8*2 | 22 (Senegal) | 11 (Uganda) |
| CYP2C8*3 | 5 (Mozambique) | 0 (Tanzania) |
| CYP2C8*4 | 0.6 (Tanzania) | 0 (Ghana) |
| CYP2C9*2 | 19 (Morocco) | 0 (multiple populations)a |
| CYP2C9*3 | 35 (Libya) | 0 (multiple populations)b |
| CYP2C19*2 | 33 (Igbo) | 6 (Ghana) |
| CYP2C19*3 | 7 (South Africa MA) | 0 (multiple populations)c |
| CYP2D6*3 | 9 (San) | 0 (multiple populations)d |
| CYP2D6*4 | 9 (San) | 0 (DRC, Kenya, Ethiopia, Kikuyu, South Africa Bantu, Tanzania, Yoruba) |
| CYP2D6*9 | 0 (All populations) | 0 (All populations) |
| CYP2D6*10 | 19 (South Africa Venda) | 0 (DRC, Kenya, South Africa Bantu, Zimbabwe Shona) |
| CYP2D6*17 | 34 (Shona) | 0 (DRC) |
| CYP2D6*29 | 29 (Igbo) | 2 (San) |
| CYP3A5*3 | 92 (Morocco) | 4 (Uganda) |
| CYP3A5*6 | 33 (North Sudan, Malawi Ngoni) | 4 (Morocco) |
| CYP3A5*7 | 23 (Gambia) | 0 (North Sudan, Ethiopia) |
Data are from Supplementary Table 1, Table 2.
CYP, cytochrome P450; DRC, Democratic Republic of Congo; MA, mixed ancestry.
a
Benin, Central African Republic, Democratic Republic of Congo, Ghana, Mozambique, Namibia, Senegal, South Africa.
b
Benin, Central African Republic, Democratic Republic of Congo, Ghana, Kenya (Luo), Namibia, Nigeria, Senegal, South Africa, Sudan, Tanzania.
c
African-American, Benin, Ghana, Hausa, Igbo, Kikuyu, Luo, Maasai, San, Shona, South Africa, (Venda, Xhosa), Yoruba.
d
Central African Republic, Democratic Republic of Congo, Ethiopia, Ghana, Kenya, Namibia, Yoruba, Senegal, South Africa (Bantu, Black, Venda).