Table 1.
CYP variant | Highest reported frequency (%) (population) | Lowest reported frequency (%) (population) |
---|---|---|
CYP2B6*6 | 69 (Uganda) | 9 (South Africa MA) |
CYP2C8*2 | 22 (Senegal) | 11 (Uganda) |
CYP2C8*3 | 5 (Mozambique) | 0 (Tanzania) |
CYP2C8*4 | 0.6 (Tanzania) | 0 (Ghana) |
CYP2C9*2 | 19 (Morocco) | 0 (multiple populations)a |
CYP2C9*3 | 35 (Libya) | 0 (multiple populations)b |
CYP2C19*2 | 33 (Igbo) | 6 (Ghana) |
CYP2C19*3 | 7 (South Africa MA) | 0 (multiple populations)c |
CYP2D6*3 | 9 (San) | 0 (multiple populations)d |
CYP2D6*4 | 9 (San) | 0 (DRC, Kenya, Ethiopia, Kikuyu, South Africa Bantu, Tanzania, Yoruba) |
CYP2D6*9 | 0 (All populations) | 0 (All populations) |
CYP2D6*10 | 19 (South Africa Venda) | 0 (DRC, Kenya, South Africa Bantu, Zimbabwe Shona) |
CYP2D6*17 | 34 (Shona) | 0 (DRC) |
CYP2D6*29 | 29 (Igbo) | 2 (San) |
CYP3A5*3 | 92 (Morocco) | 4 (Uganda) |
CYP3A5*6 | 33 (North Sudan, Malawi Ngoni) | 4 (Morocco) |
CYP3A5*7 | 23 (Gambia) | 0 (North Sudan, Ethiopia) |
Data are from Supplementary Table 1, Table 2.
CYP, cytochrome P450; DRC, Democratic Republic of Congo; MA, mixed ancestry.
Benin, Central African Republic, Democratic Republic of Congo, Ghana, Mozambique, Namibia, Senegal, South Africa.
Benin, Central African Republic, Democratic Republic of Congo, Ghana, Kenya (Luo), Namibia, Nigeria, Senegal, South Africa, Sudan, Tanzania.
African-American, Benin, Ghana, Hausa, Igbo, Kikuyu, Luo, Maasai, San, Shona, South Africa, (Venda, Xhosa), Yoruba.
Central African Republic, Democratic Republic of Congo, Ethiopia, Ghana, Kenya, Namibia, Yoruba, Senegal, South Africa (Bantu, Black, Venda).