Table 3. Univariate and multivariate analyses of prognostic factors for disease-free survival or disease-specific survival of patients with early stage (stage I-II) tumors in the study cohort.
Variables | Univariate analysisa | Multivariate analysisb | ||||
---|---|---|---|---|---|---|
HR | 95 % CI | P value | HR | 95 % CI | P value | |
Disease-free survival | ||||||
Age (≥ 60/< 60 years) | 1.812 | 1.002–3.275 | 0.049 | 1.780 | 0.980–3.232 | 0.058 |
Sex (male/female) | 0.722 | 0.414–1.256 | 0.249 | |||
Tumor location (rectum/colon) | 1.576 | 0.905–2.745 | 0.108 | |||
Tumor size (≥ 5/< 5 cm) | 0.860 | 0.496–1.494 | 0.593 | |||
Bowel obstruction/perforation (yes/no) | 1.294 | 0.315–5.325 | 0.721 | |||
Differentiation grade (poor/well + moderate) | 1.857 | 1.035–3.332 | 0.038 | 1.392 | 0.747–2.594 | 0.298 |
Local invasion (T3–T4/T1–T2) | 1.255 | 0.644–2.447 | 0.505 | |||
Serum CEA level (≥ 10/ < 10 ng/mL) | 1.167 | 0.674–2.021 | 0.581 | |||
PRDX2 expression(high/low) | 2.018 | 1.143–3.561 | 0.015 | 1.856 | 1.016–3.390 | 0.044 |
Disease-specific survival | ||||||
Age (≥ 60/< 60 years) | 2.300 | 1.120–4.721 | 0.023 | 2.235 | 1.083–4.613 | 0.030 |
Sex (male/female) | 0.737 | 0.391–1.389 | 0.346 | |||
Tumor location (colon/rectum) | 1.330 | 0.708–2.496 | 0.375 | |||
Tumor size (≥ 5/< 5 cm) | 0.578 | 0.308–1.085 | 0.088 | |||
Bowel obstruction/perforation (yes/no) | 1.713 | 0.412–7.112 | 0.459 | |||
Differentiation grade (poor/well + moderate) | 2.190 | 1.146–4.183 | 0.018 | 1.585 | 0.801–3.137 | 0.186 |
Local invasion (T3–T4/T1–T2) | 1.316 | 0.605–2.864 | 0.488 | |||
Serum CEA level (≥ 10/ < 10 ng/mL) | 1.298 | 0.692–2.437 | 0.416 | |||
PRDX2 expression (high/low) | 2.377 | 1.221–4.629 | 0.011 | 2.137 | 1.062–4.299 | 0.033 |
Abbreviations: CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; PRDX2, peroxiredoxin 2; TNM, tumor-node-metastasis.
a In univariate analyses, log-rank tests were conducted.
b In the multivariate Cox proportional hazard model, only variables with P < 0.05 in univariate analysis were included and the “enter method” was applied.