Table 1. VEGFA genotype and allele frequencies of the cases and controls and their association with risk of HCC.

Polymorphism	Genotype/allele	HCC (n = 476)	controls (n = 526)	Crude OR 95% CI	Pa value	Adjusted ORb 95% CI	Pc value
VEGF	CC	359 (75.4)d	370 (70.3)	1.00		1.00
936 C/T	CT	112 (23.5)	140 (26.6)	0.83 [0.62,1.10]	0.188	0.84 [0.60,1.19]	0.325
	TT	5 (1.1)	16 (3.1)	0.32 [0.12,0.89]	0.021	0.54 [0.17,1.70]	0.295
Genotypes	CT and TT	117 (24.6)	156 (29.7)	0.77 [0.58,1.02]	0.071	0.81 [0.58,1.13]	0.221
Alleles	T	0.128	0.163
VEGF	GG	162 (34.0)	200 (38.0)	1.00		1.00
634G/C	GC	232 (48.8)	248 (47.2)	1.16 [0.88,1.52]	0.302	1.10 [0.79,1.53]	0.583
	CC	82 (17.2)	78 (14.8)	1.30 [0.89,1.88]	0.170	1.13 [0.73,1.75]	0.590
Genotypes	GC and CC	314 (66.0)	326 (62.0)	1.19 [0.92,1.54]	0.189	1.11 [0.81,1.51]	0.516
Alleles	C	0.416	0.384
VEGF	GG	254 (53.4)	296 (56.3)	1.00		1.00
1612G/A	GA	188 (39.5)	198 (37.6)	1.11 [0.85,1.44]	0.447	1.22 [0.90,1.67]	0.203
	AA	34 (7.1)	32 (6.1)	1.24 [0.74,2.06]	0.412	1.16 [0.64,2.11]	0.628
Genotypes	GA and AA	222 (46.6)	230 (43.7)	1.13 [0.88,1.44]	0.355	1.21 [0.90,1.63]	0.209
Alleles	A	0.269	0.249
VEGF	CC	301 (63.2)	290 (55.1)	1.00		1.00
2578C/A	CA	157 (33.0)	202 (38.4)	0.75 [0.58,0.98]	0.031	0.72 [0.53,0.98]	0.041
	AA	18 (3.8)	34 (6.5)	0.51 [0.28,0.92]	0.024	0.48 [0.24,0.96]	0.038
Genotypes	CA and AA	175 (36.8)	236 (44.9)	0.71 [0.55,0.92]	0.009	0.69 [0.51,0.93]	0.014
Alleles	A	0.203	0.257

^aP value for crude odds ratio (OR) and 95% confidence interval (CI).

^bAdjusted for age, gender, HBV carrier state, family history of cancer, smoking, and drinking status.

^cP value for adjusted odds ratio (OR) and 95% confidence interval (CI).

^dValues in parentheses indicate percentages.