Table 2.

Predicted area under concentration–time curve ratios (AUCRs) of secretagogue–precipitant pairs considered as weak and moderate drug–drug interactions.

Precipitant	Glipizide	Glyburide	Glimepiride	Repaglinide	Nateglinide
Atazanavir		1.28		1.29
Cefuroxime				1.47
Chlorzoxazone	1.37		1.39		1.27
Clonidine		1.95		2	1.34
Clotrimazole		2.35		3.52	1.55
Dapsone	1.40		1.43
Diflunisal	3.01		3.32		1.74
Fluconazole	2.21	2.35	2.34	1.55	2.12
Gemfibrozil	1.44		1.47		1.25
Ketoconazole		1.28		1.30
Phenytoin	1.59		1.64		1.31
Quinine				1.40
Ritonavir		1.70		1.95	1.34

Drug pairs with 2 ≤ AUCR < 5 (in bold) were considered as moderate drug–drug interactions, those with 1.25 ≤ AUCR <2 were considered as weak.