Abstract
Aim: Few studies have addressed stroke risk factors in older populations, particularly among the old-old. We examined differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults.
Methods: We followed 2,065 residents aged ≥ 60 years who had no history of stroke. Traditional risk factors for stroke were obtained from a self-administered questionnaire at baseline. We classified participants into two age categories, 60–74 years (n = 1,502) and ≥ 75 years (n = 563), and assessed whether traditional risk factors were differentially associated with stroke incidence according to age category. Hazard ratios were calculated by the Cox proportional hazards model, adjusting for confounding factors and competing risk of death.
Results: During a median follow-up of 12.8 and 7.9 years, 163 and 111 participants aged 60–74 and ≥ 75 years, respectively, developed a first stroke. Hypertension was consistently associated with increased risk of stroke, regardless of age category. Diabetes mellitus was associated with increased risk of stroke in those aged 60–74 years (hazard ratio, 1.50; 95% confidence interval, 1.00–2.25), but not in those aged ≥ 75 years (hazard ratio, 0.65; 95% confidence interval, 0.33–1.29), with significant interaction by age (P = 0.035). No traditional risk factor other than hypertension was associated with stroke among those aged ≥ 75 years.
Conclusion: Those with hypertension had significantly higher stroke risk among old people, while diabetes mellitus was differentially associated with stroke according to age category. Our findings indicate the importance of different prevention strategies for stroke incidence according to age category.
Keywords: Diabetes mellitus, Hypertension, Old-old, Stroke, Young-old
See editorial vol. 24: 258–261
Introduction
Developed countries have highly aged population structures1). Because the incidence of stroke rises markedly with age2), older people may receive more absolute benefits from the prevention of stroke than younger people. A few prospective cohort studies have shown significant associations between traditional risk factors and stroke among older people3–5), but these associations become progressively weaker with increasing age6, 7).
The variability between different age categories of older people should be recognized towards an accurate definition and classification of aging8), because the older population is extremely heterogeneous9). The rationale for this is the “young-old” and “old-old” distinction introduced by Neugarten10): the young-old are generally active and their functional capacity is usually conserved, while the old-old are mostly characterized by disability and dependency1, 11). Many previous studies have shown that old-old stroke patients have different risk profiles and stroke features than young-old stroke patients12–16). These studies have been mainly hospital-based reports, and very few prospective cohort studies have assessed stroke risk among community-dwelling old-old adults, although in this population traditional risk factors for stroke seem to be less important7, 17). It is therefore unclear whether traditional risk factors for stroke in middle-aged and young-old adults are also important in the old-old.
Aim
The aim of the present study is to examine differences in traditional risk factors for stroke among the old-old compared with the young-old in community-dwelling Japanese adults. Because the competing risk of death is not negligible, particularly among the old-old, we adjusted for competing risk of death when analyzing the associations between traditional risk factors and stroke incidence.
Methods
Study Population
The present study was a part of the Ohasama Study, a longitudinal community-based observational study in Ohasama, Iwate prefecture, Japan. The geographic and demographic characteristics of the study participants have been described previously18, 19). The total population aged ≥ 60 years was 2,614 in 1998; 2,348 provided written informed consent to participate (response rate 89.8%). The participants or their relatives completed the self-administered questionnaire between February 1 and March 28, 1998. A total of 283 participants were excluded for the following reasons: a history of stroke before the baseline survey (n = 236), unwillingness to take part in follow-up (n = 46), or relatives responding after the death of the participant (n = 1). Data from the remaining 2,065 participants were analyzed. The institutional review board of Tohoku University School of Medicine and of Pharmaceutical Sciences and the Department of Health of the Ohasama Town Government approved this study.
Traditional Risk Factors
Traditional risk factors for stroke were obtained from the baseline self-administered questionnaire. Self-reported body weight and height were used to calculate body mass index, which was classified as < 18.5, 18.5–24.9, or ≥ 25 kg/m2. Among the participants, 935 attended health checkups provided by the town in November 1997, and we compared the self-reported values at the baseline survey with the measured values at the health checkup; Pearson's correlation was 0.81 for body mass index. Hypertension was defined as a diagnosed history of hypertension or current use of antihypertensive drugs. Diabetes mellitus, hypercholesterolemia, heart disease, and kidney disease were defined as having been diagnosed with the disease, including being currently under treatment. Smoking status was categorized in three groups: current, former, and never. Alcohol intake was dichotomized as current and former/never because of the small number of respondents who answered ‘former.’ Marital status was dichotomized into married and single/divorced/widowed. Educational attainment was dichotomized into junior high school and senior high school or higher. Habitual exercise was determined by answers to the question, “How many times do you normally exercise per week?” Responses were classified as rarely/never, 1–2 hours/week, or ≥ 3 hours/week. Parental histories of hypertension and stroke were defined as positive if participants reported that one parent had a history of disease.
Follow-Up and Outcomes
Follow-up of each participant was continued until the occurrence of one of the following censoring events: stroke incidence, death, loss to follow-up because of moving away from Ohasama town, or the end of our follow-up period (November 30, 2010). Residence in Ohasama was confirmed by the residents' registration cards, which are used for pensions and social security benefits in Japan. Stroke incidence was determined by reviewing the Stroke Registration System of Iwate Prefecture, death certificates, National Health Insurance receipts, Later Elder's Insurance receipts, and questionnaires sent to each household at the time of health checkups. This information was then confirmed by checking the medical charts of Ohasama Hospital, which is the only hospital in the town and where ≥ 90% of participants had regular checkups. Among all stroke cases registered until 2010, 97.7% were confirmed by computed tomography or magnetic resonance imaging of the brain. The diagnostic criteria of stroke and its subtypes were based on the system for the Classification of Cerebrovascular Disease III by the National Institute of Neurological Disorders and Stroke20). Fatal cases of stroke were defined as death from stroke within 28 days of stroke incidence21). The present analysis considered only the first stroke incidence. Deaths from stroke ascertained only by death certificates were not included in stroke cases, as these diagnoses and dates of incidence were uncertain. Transient ischemic attacks were not included as stroke.
Statistical Analysis
Baseline characteristics of participants aged 60–74 years and ≥ 75 years were compared using the chi-square test. The Cox proportional hazards model was used to explore the associations between traditional risk factors and first stroke incidence. To weigh competing risk of death (death from causes other than stroke, such as cancer and heart disease) among the older population, the Cox model fitted a proportional subdistribution hazards regression model with weights for those who underwent competing risk of death22, 23). Person-years in the follow-up period were counted from the date of the baseline survey to the occurrence of one of the censoring events, whichever came first. For those who were lost to follow-up, the last confirmed date of their presence in Ohasama was used as the date of censoring.
A two-step process was used to determine the best model for the study. First, we used the age- and sex-adjusted Cox model to determine the separate associations of all variables with stroke incidence. Variables that fulfilled a significance of P <0.20 in these models were then simultaneously entered into a multivariate-adjusted model including age and sex24). This multivariate-adjusted analysis was performed separately by age category. We further examined whether age category modified the associations between risk factors and stroke by cross-product interaction terms. We conducted sensitivity analyses stratified by sex. Identical analyses were conducted according to the stroke subtypes of cerebral infarction and hemorrhagic stroke (intracerebral hemorrhage and subarachnoid hemorrhage combined). For missing values at baseline, the single imputation method with regression on age and sex was conducted in multivariate analyses. Because similar results were obtained before and after imputation, we present only the results with imputation.
All analyses were conducted using STATA 12.0 (StataCorp LP, College Station, TX, USA). A two-tailed P <0.05 was considered statistically significant.
Results
The baseline characteristics of participants are shown in Table 1. Significant differences in the prevalence of traditional risk factors for stroke were observed between those aged 60–74 years and those aged ≥ 75 years, except for diabetes mellitus and hypercholesterolemia.
Table 1. Baseline characteristics in the Ohasama Study, Japan, 1998.
Variables, n (%) | Total n = 2065 |
Age category |
P value | |
---|---|---|---|---|
60–74 years n = 1502 |
≥ 75 years n = 563 |
|||
Men | 840 (40.7) | 648 (43.1) | 192 (34.1) | <0.001 |
Body mass index | <0.001 | |||
<18.5 kg/m2 | 98 (5.6) | 55 (4.1) | 43 (10.8) | |
18.5.24.9 kg/m2 | 1134 (65.1) | 870 (64.6) | 264 (66.5) | |
≥ 25.0 kg/m2 | 511 (29.3) | 421 (31.3) | 90 (22.7) | |
Hypertension | 965 (46.7) | 656 (43.7) | 309 (54.9) | <0.001 |
Diabetes mellitus | 262 (12.7) | 198 (13.2) | 64 (11.4) | 0.27 |
Hypercholesterolemia | 266 (12.9) | 205 (13.7) | 61 (10.8) | 0.089 |
Heart disease | 219 (10.6) | 133 (8.9) | 86 (15.3) | <0.001 |
Kidney disease | 66 (3.2) | 38 (2.5) | 28 (5.0) | 0.005 |
Smoking status | <0.001 | |||
Current smoker | 337 (16.3) | 283 (18.8) | 54 (9.6) | |
Former smoker | 211 (10.2) | 158 (10.5) | 53 (9.4) | |
Never smoker | 1517 (73.5) | 1061 (70.6) | 456 (81.0) | |
Current drinker | 648 (31.4) | 519 (34.6) | 129 (22.9) | <0.001 |
Married | 1283 (70.7) | 1058 (79.7) | 225 (46.1) | <0.001 |
Educational attainment, junior high school | 1579 (84.8) | 1148 (83.1) | 431 (89.8) | <0.001 |
Habitual exercise | 0.030 | |||
≥ 3 hours/week | 172 (9.6) | 129 (9.7) | 43 (9.4) | |
1.2 hours/week | 286 (16.0) | 230 (17.3) | 56 (12.2) | |
Rarely/Never | 1329 (74.4) | 969 (73.0) | 360 (78.4) | |
Parental history of hypertension | 377 (18.3) | 303 (20.2) | 74 (13.1) | <0.001 |
Parental history of stroke | 566 (27.4) | 436 (29.0) | 130 (23.1) | 0.007 |
Values are the number of participants (%). Values for body mass index, marital status, educational attainment, and habitual exercise were available for 1743, 1816, 1862, and 1787 participants, respectively. P denotes the significance of the difference between age categories using the chi-square test.
The median duration of follow-up was 12.8 years among those aged 60–74 years and 7.9 years among those aged ≥ 75 years. During 16,472 person-years among those aged 60–74 years, 324 deaths and 163 incident cases of first stroke (19 fatal cases; 11.7%) were observed: 113 cerebral infarctions, 33 intracerebral hemorrhages, 15 subarachnoid hemorrhages, 1 other type, and 1 unspecified case. During 4,367 person-years among those aged ≥ 75 years, 371 deaths and 111 incident cases of first stroke (13 fatal cases; 11.7%) were observed: 89 cerebral infarctions, 21 intracerebral hemorrhages, and 1 unspecified case. Of those stroke cases ascertained only by death certificates, 3 cases were among those aged 60–74 years and 16 cases were among those aged ≥ 75 years.
Age- and sex-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for stroke incidence according to traditional risk factors among the total population (those aged ≥ 60 years) are presented in Table 2. Older age, male sex, hypertension, diabetes mellitus, heart disease, current alcohol drinking, and lower educational attainment reached significance (P <0.20) and were used in the following analyses.
Table 2. Age- and sex-adjusted hazard ratios for stroke incidence.
Variables | Age- and sex-adjusted HR (95% CI) | P value |
---|---|---|
Age (per 1 standard deviation) | 1.47 (1.32–1.63) | <0.001 |
Men (vs. women) | 1.27 (1.00–1.62) | 0.050 |
BMI, < 18.5 kg/m2 (vs. 18.5.24.9) | 1.10 (0.64–1.88) | 0.74 |
BMI, ≥ 25.0 kg/m2 (vs. 18.5.24.9) | 0.92 (0.67–1.26) | 0.61 |
Hypertension | 1.98 (1.54–2.55) | <0.001 |
Diabetes mellitus | 1.29 (0.92–1.79) | 0.14 |
Hypercholesterolemia | 0.92 (0.63–1.36) | 0.69 |
Heart disease | 1.26 (0.89–1.79) | 0.19 |
Kidney disease | 0.71 (0.34–1.50) | 0.37 |
Current smoker (vs. never) | 1.25 (0.87–1.80) | 0.22 |
Former smoker (vs. never) | 0.85 (0.53–1.34) | 0.47 |
Current drinker | 1.29 (0.97–1.72) | 0.077 |
Single/divorced/widowed (vs. married) | 0.91 (0.65–1.27) | 0.58 |
Junior high school (vs. senior high school or higher) | 1.67 (1.08–2.59) | 0.022 |
Habitual exercise, ≥ 3 hours/week (vs. rar align="center"ely/never) | 0.81 (0.50–1.30) | 0.38 |
Habitual exercise, 1–2 hours/week (vs. rarely/never) | 0.99 (0.69–1.42) | 0.97 |
Parental history of hypertension | 0.97 (0.70–1.33) | 0.83 |
Parental history of stroke | 1.10 (0.85–1.44) | 0.47 |
Each hazard ratio (HR) and 95% confidence interval (CI) was adjusted by age and sex, while age was adjusted by sex and vice versa. Age per 1 standard deviation corresponded to 7.6 years.
Older age, hypertension, diabetes mellitus, and lower educational attainment were significantly associated with stroke incidence among those aged 60–74 years after multivariate adjustment, while only hypertension was a significant risk factor for stroke among those aged ≥ 75 years (Fig. 1). The interaction of diabetes mellitus with age categories was statistically significant (P = 0.035). No significant interaction was found between age categories and any other variables. Hypertension was associated with a higher probability of stroke incidence among both those aged 60–74 years (HR, 2.12; 95% CI, 1.51–2.98) and those aged ≥ 75 years (HR, 1.59; 95% CI, 1.07–2.36). However, diabetes mellitus was associated with increased stroke risk only among those aged 60–74 years (HR, 1.50; 95% CI, 1.00–2.25), not among those aged ≥ 75 years (HR, 0.65; 95% CI, 0.33–1.29). We also conducted standard Cox regression analyses, and obtained similar results (Supplemental Table 1). Although the interaction by sex on the association of educational attainment with stroke was statistically significant among those aged 60–74 years (P = 0.012), there was little difference between men and women on the other variables (>Supplemental Table 2).
Supplemental Table 1. Multivariate-adjusted hazard ratios for stroke incidence among participants aged 60–74 years and ≥ 75 years by using the standard Cox regression model.
Variables | 60–74 years (n = 1502) HR (95% CI) |
≥ 75 years (n = 563) HR (95% CI) |
P value for interaction |
---|---|---|---|
Age (per 1 standard deviation) | 1.64 (1.23–2.18) | 1.70 (1.25–2.31) | 0.81 |
Men | 1.29 (0.88–1.91) | 1.36 (0.89–2.08) | 0.57 |
Hypertension | 2.14 (1.54–2.97) | 1.58 (1.07–2.33) | 0.15 |
Diabetes mellitus | 1.50 (1.01–2.22) | 0.64 (0.32–1.27) | 0.023 |
Heart disease | 1.45 (0.91–2.30) | 1.02 (0.60–1.73) | 0.21 |
Current drinker | 1.39 (0.93–2.06) | 0.88 (0.54.1–42) | 0.13 |
Junior high school | 1.86 (1.09–3.18) | 1.43 (0.66–3.09) | 0.59 |
Hazard ratios (HRs) given with 95% confidence intervals (CIs) were adjusted for all other variables shown in the table. Age per 1 standard deviation corresponded to 7.6 years. P denotes the significance of interaction between age categories (60–74 years and ≥ 75 years) and each variable.
Supplemental Table 2. Multivariate-adjusted hazard ratios for stroke incidence according to age category and sex.
Variables | 60–74 years (n = 1502) |
≥ 75 years (n = 563) |
||||
---|---|---|---|---|---|---|
Men (n = 648) HR (95% CI) |
Women (n = 854) HR (95% CI) |
P value for interaction |
Men (n = 192) HR (95% CI) |
Women (n = 371) HR (95% CI) |
P value for interaction |
|
Age (per 1 standard deviation) | 1.43 (0.96–2.12) | 1.56 (1.03–2.35) | 0.64 | 1.29 (0.77–2.17) | 1.24 (0.84–1.81) | 0.83 |
Hypertension | 2.25 (1.37–3.69) | 1.97 (1.23–3.16) | 0.72 | 1.78 (0.90–3.50) | 1.47 (0.91–2.39) | 0.63 |
Diabetes mellitus | 1.52 (0.88–2.60) | 1.54 (0.83–2.83) | 0.96 | 0.21 (0.03–1.52) | 0.89 (0.41–1.94) | 0.2 |
Heart disease | 1.29 (0.69–2.43) | 1.47 (0.74–2.94) | 0.9 | 1.25 (0.54–2.87) | 0.86 (0.42–1.76) | 0.55 |
Current drinker | 1.37 (0.81–2.30) | 1.46 (0.77–2.76) | 0.96 | 1.06 (0.56–1.98) | 0.85 (0.39–1.83) | 0.63 |
Junior high school | 1.04 (0.58–1.88) | 7.06 (1.82–27.48) | 0.012 | 1.18 (0.42–3.32) | 1.61 (0.50–5.22) | 0.72 |
Hazard ratios (HRs) given with 95% confidence intervals (CIs) were adjusted for all other variables shown in the table. Age per 1 standard deviation corresponded to 7.6 years. P denotes the significance of interaction between sex and each variable.
Results were confirmatory when cerebral infarction was assessed instead of total stroke, although statistical significance was reduced because of smaller event numbers. Diabetes mellitus was associated with a higher risk of cerebral infarction only among those aged 60–74 years, but not among those aged ≥ 75 years (Supplemental Table 3). To predict hemorrhagic stroke, current alcohol drinking was the only significant risk factor among those aged 60–74 years (Supplemental Table 4).
Supplemental Table 3. Multivariate-adjusted hazard ratios for cerebral infarction among participants aged 60–74 years and ≥ 75 years.
Variables | 60–74 years (n = 1502) HR (95% CI) |
≥ 75 years (n = 563) HR (95% CI) |
P value for interaction |
---|---|---|---|
Age (per 1 standard deviation) | 1.57 (1.11–2.22) | 1.32 (0.94–1.86) | 0.57 |
Men | 1.47 (0.93–2.33) | 0.99 (0.61–1.62) | 0.19 |
Hypertension | 2.66 (1.74–4.05) | 1.40 (0.91–2.15) | 0.021 |
Diabetes mellitus | 1.72 (1.07–2.76) | 0.77 (0.37–1.60) | 0.05 |
Heart disease | 1.32 (0.76–2.30) | 0.96 (0.52–1.77) | 0.29 |
Current drinker | 1.19 (0.75–1.89) | 1.08 (0.64–1.85) | 0.36 |
Junior high school | 1.68 (0.91–3.10) | 1.28 (0.56–2.96) | 0.7 |
Hazard ratios (HRs) given with 95% confidence intervals (CIs) were adjusted for all other variables shown in the table. Age per 1 standard deviation corresponded to 7.6 years. P denotes the significance of interaction between age categories (60–74 years and ≥ 75 years) and each variable.
Supplemental Table 4. Multivariate-adjusted hazard ratios for hemorrhagic stroke among participants aged 60–74 years and ≥ 75 years.
Variables | 60–74 years (n = 1502) HR (95% CI) |
≥ 75 years (n = 563) HR (95% CI) |
P value for interaction |
---|---|---|---|
Age (per 1 standard deviation) | 1.29 (0.78–2.14) | 0.80 (0.37–1.72) | 0.37 |
Men | 0.55 (0.26–1.16) | 1.82 (0.79–4.18) | 0.25 |
Hypertension | 1.30 (0.71–2.38) | 2.18 (0.81–5.87) | 0.46 |
Diabetes mellitus | 1.08 (0.49–2.41) | 0.33 (0.04–2.50) | 0.36 |
Heart disease | 1.13 (0.44–2.86) | 1.30 (0.43–3.90) | 0.84 |
Current drinker | 2.24 (1.09–4.61) | 0.60 (0.20–1.78) | 0.3 |
Junior high school | 2.10 (0.77–5.78) | 2.27 (0.30–17.39) | 0.94 |
Hazard ratios (HRs) given with 95% confidence intervals (CIs) were adjusted for all other variables shown in the table. Age per 1 standard deviation corresponded with 7.6 years. P denotes the significance of interaction between age categories (60–74 years and ≥ 75 years) and each variable.
Discussion
The present cohort study demonstrated that hypertension was consistently associated with increased risk of stroke regardless of age category, and that diabetes mellitus was not associated with excess risk of stroke among those aged ≥ 75 years. No traditional risk factor other than hypertension was associated with first stroke among those aged ≥ 75 years.
Traditional risk factors had weaker associations with stroke among those aged ≥ 75 years than among those aged 60–74 years. This finding supports the argument that the associations between traditional risk factors and stroke are attenuated with advancing age6, 7). There are two possible explanations for this finding6). First, survivors with risk factors in the old-old age group may differ through selection. Those who are susceptible to risk factors are more likely to have had events earlier in life, and survival to old age with risk factors may be an indicator that they are less susceptible to such risk factors6). Second, the impact of some risk factors may be modified because of physiologic changes that occur during the aging process. Such changes can be amplified in old-old adults, who are mostly characterized by vulnerability1, 11). These cannot be separated, and both would contribute to the attenuated associations with advancing age. Some traditional risk factors such as smoking and obesity had no association with stroke incidence irrespective of age category in this population of those aged ≥ 60 years, which suggests that the attenuated associations of traditional risk factors with stroke would have begun already at young-old age.
Hypertension and diabetes mellitus are well-known risk factors for stroke incidence25). In the present study, hypertension had consistently significant associations with stroke, while diabetes mellitus had no association with stroke among those aged ≥ 75 years. The lower prevalence of diabetes mellitus than that of hypertension suggests that a larger sample is needed to detect a true association between diabetes mellitus and stroke than is needed to detect an association between hypertension and stroke. Nevertheless, in our study, the association between diabetes mellitus and stroke was positive among those aged 60–74 years and negative among those aged ≥ 75 years, with significant interaction for these age categories (Fig. 1; P = 0.035).
A prospective cohort study showed that only higher blood pressure was associated with stroke among community-dwelling adults aged 85 years17). Pooling individual data from 10 Japanese cohorts demonstrated the positive associations between blood pressure and death from cardiovascular disease even among the old-old, with a greater strength observed in younger age groups26). Recent intervention trials supported that treatment of hypertension contributed to stroke prevention in older patients27). Taken together, hypertension appears to be a major risk factor for stroke even among the old-old, although the contribution of hypertension to stroke becomes progressively weaker with increasing age6, 7, 13, 28).
Inconsistent findings were reported on the associations between diabetes mellitus and stroke among older adults4, 6, 7). Hospital-based stroke registries showed that old-old stroke patients had significantly lower prevalence of diabetes mellitus than other age groups12–16, 29, 30). Diabetes mellitus is strongly associated with other cardiovascular risk factors, such as hypertension and dyslipidemia31, 32). The weaker contribution of diabetes mellitus with advancing age can be explained by its coexistence with other cardiovascular risk factors, which results in fatal cardiovascular events at a younger age15, 31). The aforementioned survival bias6) may be more marked in diabetes mellitus than in other risk factors, although this remains to be proved. Previous studies have shown that functional capacity or psychosocial status, such as social role19), cognitive impairment33), and depression34), are significantly associated with stroke incidence even after adjusting for traditional risk factors among old-old adults. For those aged ≥ 75 years, these factors are likely to have stronger associations with stroke incidence than traditional risk factors.
Significant interaction by sex was observed only for educational attainment; those whose educational attainment was junior high school had significantly higher risk of stroke than those whose educational attainment was senior high school or higher, but this association was found only for women. This result is consistent with a recent review indicating that low socioeconomic status is associated with an increased risk of stroke, and that the association might be stronger in women than in men35). However, this association is partially inconsistent among Japanese women; for example, one study found a U-shaped association (women whose educational attainment was high school had the lowest risk of stroke36)). We could not determine whether there was a U-shaped association in the present study, because the proportion of women whose educational attainment was college or higher was very low (3.7%). Further studies are needed to clarify the association between educational attainment and stroke in Japan, because assessing socioeconomic status in women (particularly partnered women) is challenging37) and cultural differences might be expected to influence socioeconomic inequalities in women's health38).
The present study must be interpreted within the context of its potential limitations. First, information on all risk factors was self-reported and misclassification is possible. In prospective studies, misclassification is typically considered nondifferential and therefore is expected to lead to an underestimation of risk. If the validity of self-reported histories reduces with increasing age, this could partly explain the weaker associations of traditional risk factors with stroke among those aged ≥ 75 years than among those aged 60–74 years. However, the prevalence of undetected hypertension and diabetes mellitus may be relatively small because of nationwide health screenings in Japan39). Second, our study population consisted of residents from a Japanese rural district, and our current findings might not be generalizable to Western populations, in whom not stroke but myocardial infarction is the dominant cardiovascular complication. Nevertheless, the representativeness of the sampled area will be high because of the high response rate (89.8%). Third, the validity of parental histories of hypertension and stroke remains questionable. Recall of parental hypertension may be difficult to confirm because of the less frequent opportunity for measuring blood pressure or different hypertension criteria when the participants' parents were alive and because of recall bias40). Self-reported parental history of stroke is sometimes inaccurate; in the Framingham Offspring Study, a positive offspring report of parental early-onset stroke had relatively low predictive value, whereas a negative offspring report had high predictive value41). Other factors that are easier to remember (e.g., parental longevity) may be more accurate predictors for stroke than offspring reports of parental history of hypertension and stroke42). Finally, we cannot estimate entire confounding factors (e.g., mental disorders or physical activities) that may be associated with stroke risk. Despite these limitations, we could examine the associations between traditional risk factors and stroke incidence among old-old adults, about which there is little evidence. Identification and quantitative assessment of particular risk factors for stroke among the old-old in the present study has important preventive implications. In addition, a better knowledge of age differences in stroke risk profiles may be useful for intervention points for risk modification.
Conclusion
The present study showed that the sets of traditional risk factors for stroke among those aged 60–74 and ≥ 75 years differed: all older people with hypertension had consistently high stroke risk, while the association between diabetes mellitus and stroke was weakened in those aged ≥ 75 years at baseline. No traditional risk factors other than hypertension were associated with stroke among those aged ≥ 75 years. If survival bias (i.e., those who are susceptible to risk factors have a higher probability of stroke incidence earlier in life) attenuates the associations between traditional risk factors and stroke with increasing age, earlier treatment of risk factors such as diabetes mellitus before ≥ 75 years would be useful in preventing stroke incidence. Our findings support the importance of different prevention strategies for stroke incidence according to age category.
Acknowledgements
We are grateful to the residents in Ohasama, and to staff members of the Hanamaki City Government, Ohasama Hospital, and Iwate Prefecture Stroke Registry for their valuable support on the Ohasama study project.
This study was supported by Grants for Scientific Research (23249036, 23390171, 24390084, 24591060, 24790654, 25253059, 25461083, 25461205, 25860156, 26282200, and 26860093) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan; a Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS) fellows (25*7756, 25*9328, 26*857 and 27*656); the Japan Arteriosclerosis Prevention Fund; Intramural Research Fund (22-4-5) for Cardiovascular Diseases of National Cerebral and Cardiovascular Center; and a Health Labour Sciences Research Grant (H26-Junkankitou [Seisaku]-Ippan-001) from the Ministry of Health, Labour, and Welfare; and A Scheme to Revitalize Agriculture and Fisheries in Disaster Area through Deploying Highly Advanced Technology (NouEi 2-02) from the Ministry of Agriculture, Forestry and Fisheries, Japan.
Conflicts of Interest
There are no conflicts of interest related to the present study.
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