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. 2016 Nov 4;8(12):18773–18791. doi: 10.18632/oncotarget.13095

Figure 4.

Figure 4

(A–C) Pro-apoptotic effects of mmu-miR-96-5p, -1912-5p, -147b-5p and -3073a-3p in ovarian cancer cell lines and combined action with carboplatin. Influence of mmu-miR-96-5p, -1912-5p, -147b-5p and -3073a-3p on cytochrome c release (A) and apoptosis rate (B). The miRNA mimics were individually transfected into SKOV3, OVCAR3, TOV21G, TOV112D, A2780 and A2780-cis cells (conditions of the experiment as described in Figure 1). For controls cells were treated with either 8 μM carboplatin or 0.25 nM paclitaxel. Synergistic pro-apoptotic effects of transfected miRNA mimics together the chemo drug carboplatin (C). 5.5 μM carboplatin were added 6 h after transfection. To compare the effect of the transfected miRNAs a non-targeting control (NT) was used. Statistical analysis was performed by two-way ANOVA followed by Bonferroni post-test [n = 3; Mean ± SD, *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001].