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. 2016 Nov 15;8(12):19156–19171. doi: 10.18632/oncotarget.13353

Figure 3. Evolutionary conservation of gene networks related to DDR.

Figure 3

A, B. Gene networks for cluster 5 (A) and cluster 7 (B). For each cluster, networks of both yeast (left) and human (right) orthologous genes are shown. Gene Ontology (GO) functional annotations determined in yeast are indicated (on both yeast and human orthologs): DDR, yellow node fill; transport/secretion, pink node fill; proteosome/ubiquitination/degradation, light-blue node fill; chromosome/chromatin association, blue node outline. Bold font, cisplatin- and UV_rad sensitizing candidates; red font: cisplatin-sensitizing. Edges: physical interaction (red) or signaling interaction (green). Functionally connected, but not orthologous to yeast counterparts in the corresponding clusters, human genes are shown as hexagons. C. Schematic representation of defined components of the Nucleotide Excision Repair NER) pathway enriched in cluster 7 (black font) and associated signaling partners (brown).