Table 2. Fold increases of top metabolites from the 1o Tumor1 and metastatic sites.
| Metabolite | 1o Tumor vs: | |||
|---|---|---|---|---|
| Brain | Liver | Lung | Spine | |
| Biotripyrrin | 4.2 | 14.0 | 7.5 | 34.6 |
| 2-Amino-3-Carboxymuconic Acid Semialdehyde | 17.3 | 14.7 | 2.9 | 12.0 |
| L-Thyroxine | ----2 | 18.0 | 2.5 | 7.9 |
| Phosphatidylinositol Trisphosphate (PIP3) (18:0/16:1) | 3.5 | 4.6 | 6.7 | 3.9 |
| Lysophosphatidylethanolamine (LysoPE) (15:0/0:0) | 5.4 | 3.7 | 2.3 | 3.7 |
| L-Dihydroorotic Acid | 4.0 | 3.8 | 2.0 | 3.6 |
| Cholesterol Ester (14:1) | 2.7 | 3.3 | 4.8 | 3.7 |
| Cholesterol Ester (20:4) | 2.0 | 2.2 | 2.7 | 3.4 |
| Brain vs: | ||||
| 1o Tumor | Liver | Lung | Spine | |
| Neurotensin 1-10 | 85 | 3.8 | 100 | 9.9 |
| Tryptophyl-Tryptophan | 60 | 24 | ---- | 36 |
| Phosphotidylethanolamine (PE) (18:3/14:1) | 23 | 2.2 | ---- | 9.6 |
| Phosphotidylglycerolphosphate (PGP) (16:1/16:1) | 8.0 | 4.5 | ---- | ---- |
| Liver vs: | ||||
| 1o Tumor | Brain | Lung | Spine | |
| N1,N8 Diacetylspermidine | 42 | 2.8 | ---- | 2.0 |
| 1-Phenylethylamine | 2.5 | 2.1 | 19.7 | 5.2 |
| Pantetheine | ---- | ---- | 7.3 | ---- |
| Lung vs: | ||||
| 1o Tumor | Brain | Liver | Spine | |
| CL3 | ---- | ---- | ---- | ---- |
| Arginyl-Proline | 4.6 | 5.3 | 22 | 3.4 |
| DG4 (14:0/24:1/0:0), (16:1/22:0/0:0), (18:1/20:0/0:0) | 2.9 | 4.7 | 9.7 | 2.5 |
| Putreanine | 3.5 | 3.3 | 7.9 | 3.1 |
| Spine vs: | ||||
| 1o Tumor | Brain | Liver | Lung | |
| Methionyl-Proline | 71 | 20.8 | 3.1 | 44 |
| Asparaginyl-Glutamate | ---- | 26.6 | 16.6 | ---- |
| Gentisate Aldehyde | ---- | 26.6 | 16.6 | ---- |
| Dityrosine | 22.4 | 12.6 | 2.5 | 4.8 |
| PIP2 (16:0/20:1), (16:0/22:4), & (18:0/18:1) | 21.8 | 15.3 | 2.3 | 20.5 |
| 4-Guanidinobutanoic Acid | ---- | 20.9 | ---- | 2.3 |
| 5-Methyldeoxycytidine | ---- | 16.6 | 4.5 | ---- |
| Ferrocytochrome | 6.4 | 14.8 | 8.9 | 6.9 |
| Pentacaboxylporphrinyl | ---- | 10.2 | 5.2 | 5.5 |
| SCICAR5 | ---- | 7.9 | 4.3 | 8.0 |
| 4-Aminobutyraldehyde | 6.1 | 6.1 | 5.3 | 2.5 |
| N2, N2-Dimethylguanosine | ---- | 6.6 | 6.9 | 3.3 |
| D-Lactaldehyde | 6.2 | 6.6 | 6.1 | 2.5 |
| 7,8-Dihyderoneopterin | 3.1 | 3.9 | 2.9 | 2.0 |
11o Tumor denotes primary tumor. 2A dash indicates that the metabolite was below the detection limit in that organ. 3CL denotes cardiolipins: (16:0/16:0/18:1(9Z)/18:1(9Z)), (16:0/16:0/18:1(11Z)/18:1(11Z)), (16:0/16:0/18:1(9Z)/18:1(11Z)), & (16:1 (9Z)/18:0/16:1(9Z)/18:0). 4DG denotes diacylglycerol. 5SCIAR denotes: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate.