Table 2. Multivariate analysis to identify factors that predict survival in all patients.

Variables	Hazard Ratio (HR)	95% Confidence Interval (CI)	P value
Factors associated with PFS
Age ≥45	1.333	1.129-1.574	0.001
2016 WHO CNS	0.932	0.897-0.967	<0.001
1p/19q-codeleted	0.432	0.323–0.578	<0.001
IDH-mutant	0.403	0.317-0.512	<0.001
MGMT-Methylated	0.748	0.616-0.907	0.003
GTR	0.789	0.659-0.945	0.010
Factors associated with OS
Age ≥45	1.269	1.047-1.538	0.015
2016 WHO CNS	0.919	0.880-0.961	<0.001
1p/19q-codeleted	0.421	0.295–0.602	<0.001
IDH-mutant	0.354	0.265-0.473	<0.001
MGMT-Methylated	0.793	0.634-0.990	0.041
GTR	0.694	0.565-0.853	0.001

Abbreviation: HR, hazard ratio; 95% CI, 95% confidence interval; PFS, progression-free survival; OS, overall survival; WHO, world health organization; CNS, central nervous system; IDH, isocitrate dehydrogenase; MGTM, O⁶-methylguanine-DNA methyltransfer; GTR, gross total resection;