Abstract
Inoculation of syngeneic IgE into 2- to 12-day-old mice results in prolonged synthesis of anti-IgE antibodies without further challenge. These anti-IgE antibodies may be largely responsible for the long-term inhibition of synthesis of IgE that is known to result from a perinatal challenge with IgE. This conclusion is supported by the effect of passive inoculation of syngeneic polyclonal anti-IgE antibodies into young mice, which similarly results in selective inhibition of IgE synthesis. Further evidence is the close relationship between the age dependency of IgE-induced inhibition of subsequent IgE synthesis and the ability of IgE to induce anti-IgE antibodies. IgE synthesis was monitored at the level of secretion by B cells as well as serum IgE levels and IgE antibody responses.
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Selected References
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- Bozelka B. E., McCants M. L., Salvaggio J. E., Lehrer S. B. Effects of anti-epsilon on total and specific IgE levels in adult mice. Int Arch Allergy Appl Immunol. 1985;78(1):51–56. doi: 10.1159/000233862. [DOI] [PubMed] [Google Scholar]
- Bozelka B. E., McCants M. L., Salvaggio J. E., Lehrer S. B. IgE isotype suppression in anti-epsilon-treated mice. Immunology. 1982 Jul;46(3):527–532. [PMC free article] [PubMed] [Google Scholar]
- Chen S. S., Katz D. H. IgE class-restricted tolerance induced by neonatal administration of soluble or cell-bound IgE. J Exp Med. 1983 Feb 1;157(2):772–788. doi: 10.1084/jem.157.2.772. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chen S. S., Liu F. T., Katz D. H. IgE class-restricted tolerance induced by neonatal administration of soluble or cell-bound IgE. Cellular mechanisms. J Exp Med. 1984 Oct 1;160(4):953–970. doi: 10.1084/jem.160.4.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cooper M. D., Kearney J. F., Gathings W. E., Lawton A. R. Effects of anti-Ig antibodies on the development and differentiation of B cells. Immunol Rev. 1980;52:29–53. doi: 10.1111/j.1600-065x.1980.tb00329.x. [DOI] [PubMed] [Google Scholar]
- Dessein A. J., Parker W. L., James S. L., David J. R. IgE antibody and resistance to infection. I. Selective suppression of the IgE antibody response in rats diminishes the resistance and the eosinophil response to Trichinella spiralis infection. J Exp Med. 1981 Feb 1;153(2):423–436. doi: 10.1084/jem.153.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gause A., Yoshida N., Kappen C., Rajewsky K. In vivo generation and function of B cells in the presence of a monoclonal anti-IgM antibody: implications for B cell tolerance. Eur J Immunol. 1987 Jul;17(7):981–990. doi: 10.1002/eji.1830170714. [DOI] [PubMed] [Google Scholar]
- Haba S., Nisonoff A. Immunological responsiveness of neonatal A/J mice to isotypic determinants of syngeneic IgE. J Exp Med. 1988 Aug 1;168(2):713–724. doi: 10.1084/jem.168.2.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haba S., Nisonoff A. Induction of high titers of anti-IgE by immunization of inbred mice with syngeneic IgE. Proc Natl Acad Sci U S A. 1987 Jul;84(14):5009–5013. doi: 10.1073/pnas.84.14.5009. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haba S., Ovary Z., Nisonoff A. Clearance of IgE from serum of normal and hybridoma-bearing mice. J Immunol. 1985 May;134(5):3291–3297. [PubMed] [Google Scholar]
- Manning D. D. Heavy chain isotype suppression: a review of the immunosuppressive effects of heterologous anti-Ig heavy chain antisera. J Reticuloendothel Soc. 1975 Jul;18(1):63–86. [PubMed] [Google Scholar]
- Marshall J. S., Bell E. B. Induction of an auto-anti-IgE response in rats I. Effects on serum IgE concentrations. Eur J Immunol. 1985 Mar;15(3):272–277. doi: 10.1002/eji.1830150312. [DOI] [PubMed] [Google Scholar]
- Marshall J. S., Bell E. B. Induction of an auto-anti-IgE response in rats. III. Inhibition of a specific IgE response. Immunology. 1989 Mar;66(3):428–433. [PMC free article] [PubMed] [Google Scholar]
- Sedgwick J. D., Holt P. G. Kinetics and distribution of antigen-specific IgE-secreting cells during the primary antibody response in the rat. J Exp Med. 1983 Jun 1;157(6):2178–2183. doi: 10.1084/jem.157.6.2178. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tung A. S., Ju S. T., Sato S., Nisonoff A. Production of large amounts of antibodies in individual mice. J Immunol. 1976 Mar;116(3):676–681. [PubMed] [Google Scholar]