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. 1990 May;87(9):3383–3385. doi: 10.1073/pnas.87.9.3383

Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.

M Sakurai 1
PMCID: PMC53904  PMID: 2159149

Abstract

In cerebellar Purkinje cells, conjunctive stimulation of parallel fibers and the climbing fiber causes long-term depression of parallel fiber-Purkinje cell transmission. It has been postulated that calcium is an intracellular mediator of the climbing fiber to induce this synaptic modification. To directly test the hypothesis, a calcium-chelating agent, EGTA, was intracellularly injected into Purkinje cells. In these injected cells, conjunctive stimulation failed to induce depression. Instead, it caused potentiation similar to that observed after repetitive stimulation of parallel fibers alone.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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