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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1990 May;87(9):3526–3529. doi: 10.1073/pnas.87.9.3526

Metastability of the folded states of globular proteins.

J D Honeycutt 1, D Thirumalai 1
PMCID: PMC53934  PMID: 2333297

Abstract

The possibility that several metastable minima exist in which the folded forms of a polypeptide chain have similar structural characteristics but different energies is suggested. The validity of this hypothesis is illustrated with the aid of simulation methods on a model protein that folds into a beta-barrel structure. Some implications of this hypothesis such as the existence of multiple pathways with intermediates for protein folding are discussed.

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Selected References

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