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. 2016 Jul 18;5(7):e242. doi: 10.1038/oncsis.2016.51

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Copyright © 2016 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The direct PPI links between the genes with frequent copy number alterations in the high-risk group and 5-FU activity-related genes. 5-FU activity-related genes: genes involved in 5-FU transport, metabolism and other downstream effects (such as DNA repair, apoptosis and cell cycle regulation). The green nodes denoted 5-FU activity-related genes. The red/blue nodes denoted genes with amplification or deletion in the high-risk group. The triangular nodes were the genes overlapped between the genes with frequent copy number alterations and 5-FU activity-related genes.