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. 2017 Apr 1;144(7):1317–1327. doi: 10.1242/dev.140434

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Aberrant Fsp-Cre;Ptch1^fl/fl histology may be due to activated canonical hedgehog signaling. (A,B) Hematoxylin and Eosin-stained (A) Cre- and (B) Fsp-Cre; SmoM2 TEBs from 6-week-old mice, showing perturbed histology and increased stromal condensation. (C) Quantification of perturbed TEBs. (D,E) Fluorescent mount of (D) Cre- and (E) Fsp-Cre; SmoM2 glands at 8 weeks. (F) Quantification showing a slight reduction of fat pad filling in mutants. (G,H) Hematoxylin and Eosin-stained (G) Cre- and (H) filled-in Fsp-Cre; SmoM2 ducts. (I) BrdU quantification showing no difference in TEBs at 6 weeks and ducts at 8 weeks. (J) ERα quantification showing no difference at 8 weeks. (K) PR quantification showing a small increase in mutants at 8 weeks. Data are displayed as mean±s.e.m. Unpaired t-test was used for analysis. *P<0.05. n.s., not significant. Insets (B,H) show histologically normal structures. Scale bars: 50 µm in A,B,G,H; 0.5 mm in D,E.