Figure 3. Coupling energies at the α-helix and Ω-loop binding pockets.

(A) α-helix interface. (B) Ω-loop interface. The gray and green ribbons represent the main polypeptide chain of TEAD and YAP, respectively. The C_α of the mutated amino acids are represented by spheres. The coupling energies (ΔΔG_int) between the different residues are symbolized by lines. Yellow lines: −1 kcal/mol < ΔΔG_int < −0.5 kcal/mol. Red lines: ΔΔG_int < −1 kcal/mol.

DOI: http://dx.doi.org/10.7554/eLife.25068.008