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. 2017 Feb 28;8(13):21994–22002. doi: 10.18632/oncotarget.15777

Figure 1. Assessment of methylation intratumor and intertumor heterogeneity of localized lung adenocarcinomas.

Figure 1

(a) Unsupervised hierarchical clustering of intratumoral DNA methylation. Columns are the tumor regions and rows are the DNA methylation status (beta values; ranged from 0 to 1) for the top 1% CpG probes (n = 4, 855). Dark blue denotes low and yellow indicates high methylation level. (b) Unsupervised hierarchical clustering of intertumoral DNA methylation across the cohort of 11 patients for the top 1% CpG probes (n = 3, 879). (c) Top: DNA methylation CpG probes are mapped to gene regions relatively to the proximity to CpG island. Bottom: Genomic distributions of the CpG probes obtained from 1% probes and 100% probes.