Fig. 3.

Covariation patterns of nucleoside RT inhibitor (NRTI)-associated tenofovir disoproxil fumarate (TDF)-regimen associated mutations (TRAMs) in a network created from the adjacency matrix of phi correlation coefficients for each pair of NRTI TRAMs. Each edge in the network represents a strongly significant correlation (phi ≥ 0.1 and an adjusted p < 0.05) and the thickness of the edge is proportional to the strength of the correlation (phi) of a pair. Shown in orange are the NRTI TRAMs that were strongly associated with K65R: A62V, S68G/N/D, T69deletion, K70T, V75M and Y115F.